LBR and LMNB1

Number of citations of the paper that reports this interaction (PMID 12490158)
13

Data Source:
HPRD (in vivo)

		LBR	LMNB1
Gene Name		lamin B receptor	lamin B1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Integral Component Of Nuclear Inner Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Membrane
	Molecular Function	DNA Binding Protein Binding Lamin Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Poly(A) RNA Binding Chromo Shadow Domain Binding	Structural Molecule Activity Phospholipase Binding
	Biological Process	Cholesterol Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Pathways		Cholesterol biosynthesis Metabolism of lipids and lipoproteins	Apoptotic cleavage of cellular proteins DNA Damage/Telomere Stress Induced Senescence Mitotic Prophase Apoptotic execution phase Cellular Senescence Meiotic synapsis Depolymerisation of the Nuclear Lamina Nuclear Envelope Breakdown Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase M Phase Cell Cycle, Mitotic Formation of Senescence-Associated Heterochromatin Foci (SAHF) Programmed Cell Death Breakdown of the nuclear lamina Nuclear Envelope Reassembly Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase
Drugs
Diseases
GWAS			Parkinson's disease (motor and cognition) ( 22658654)
Protein-Protein Interactions		11 interactors: AKAP8L CBX3 CBX5 FNBP4 HIST1H3A HIST2H4A LMNB1 MECP2 PRM1 SRPK1 YWHAG	23 interactors: ABCG8 ATF4 CASP3 CASP6 CDK1 GIT2 GZMA GZMB LBR LMNA MBIP MELK PLEC PRKCA PRKCB PRKCD PRPH SERPINA3 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ
Entrez ID		3930	4001
HPRD ID		02488	01036
Ensembl ID		ENSG00000143815	ENSG00000113368
Uniprot IDs		Q14739	B4DZT3 P20700
PDB IDs		2DIG	2KPW 3JT0 3TYY 3UMN
Enriched GO Terms of Interacting Partners?		Chromatin Silencing DNA Packaging Chromosome Organization Negative Regulation Of Gene Expression, Epigenetic DNA Conformation Change Chromatin Organization DNA Replication-dependent Nucleosome Assembly Gene Silencing DNA Methylation On Cytosine Chromatin Silencing At RDNA Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process DNA Methylation Methylation DNA Modification DNA Metabolic Process Nucleosome Assembly Histone H4-K20 Demethylation Chromatin Assembly Nucleosome Organization Catecholamine Secretion Chromatin Modification Chromatin Assembly Or Disassembly Negative Regulation Of Megakaryocyte Differentiation Proprioception Protein-DNA Complex Assembly Regulation Of Synaptic Plasticity Chromatin Remodeling Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Sperm Chromatin Condensation Regulation Of RNA Metabolic Process Cardiolipin Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Respiratory Gaseous Exchange By Neurological System Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Neuromuscular Process Controlling Posture Regulation Of Synaptic Transmission Regulation Of Respiratory System Process Regulation Of Gene Expression Glucocorticoid Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process	Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Nuclear Envelope Organization Execution Phase Of Apoptosis Apoptotic Signaling Pathway Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nucleus Organization Peptidyl-threonine Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Histone H3-T6 Phosphorylation Positive Regulation Of Cell Death Cellular Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Histone Phosphorylation Peptidyl-amino Acid Modification Intracellular Signal Transduction Positive Regulation Of Hydrolase Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Apoptotic Process Response To Oxidative Stress Positive Regulation Of Catalytic Activity Endomembrane System Organization Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Catalytic Activity Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of MAP Kinase Activity Regulation Of Mitochondrion Organization Regulation Of Platelet Aggregation Membrane Organization Negative Regulation Of Glucose Transport Regulation Of Phosphorylation Regulation Of MAP Kinase Activity
Tagcloud ?		absent antiserum b1 cardiomyocyte cast discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamin lamina lap1 lap2 libraries localize mabs muscular myocyte nuclei phage recognize rim spots	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		absent antiserum b1 cardiomyocyte cast discs doubt dreifuss dystrophy edmd emerin emery explanation intercalated intranuclear lamina lap1 lap2 libraries localize mabs muscular myocyte nuclei phage recognize rim spots	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lcp1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?		lamin