LBR and PRM1

Number of citations: 0 (PubMedID 14701833)
Data Source: HPRD (in vitro)

		LBR	PRM1
Name		lamin B receptor	protamine 1
Structure			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Lamina Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Delta14-sterol Reductase Activity Chromo Shadow Domain Binding NADPH Binding Chromatin-protein Adaptor Activity	DNA Binding Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Cholesterol Biosynthetic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Biosynthetic Process Neutrophil Differentiation Random Inactivation Of X Chromosome	Spermatogenesis Cell Differentiation Chromosome Condensation Sperm DNA Condensation Chromosome Organization
Pathways		Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity	Replacement of protamines by nucleosomes in the male pronucleus
Diseases		HEM skeletal dysplasia; Greenberg dysplasia Pelger-Huet anomaly	None
GWAS		Delirium ( 29631748 ) LDL cholesterol levels in HIV infection ( 33109212 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 )	Asthma ( 31959851 ) Bulimia nervosa ( 23568457 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Multiple sclerosis ( 22190364 31604244 ) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376 ) Obesity-related traits ( 23251661 ) Primary biliary cirrhosis ( 22961000 )
Novel Interactors		1 novel interactors: SFTPD	1 novel interactors: GRIN2A
Interacting Genes		13 interacting genes: AKAP8L CALD1 CBX3 CBX5 CD81 FNBP4 H4C14 KPNB1 LMNB1 PRM1 SRPK1 SRPK2 YWHAG	3 interacting genes: CLK2 LBR SRPK1
Entrez ID		3930	5619
HPRD ID		02488	01688
Ensembl ID		ENSG00000143815	ENSG00000175646
Uniprot IDs		Q14739	P04553 Q3MN80
PDB IDs		2DIG	Not available
GO Terms Enriched among Interactors		Chromatin Organization Nuclear Envelope Protein Localization To Organelle Nucleoplasm Chromatin Remodeling Heterochromatin Formation Nuclear Matrix Chromosome Sperm DNA Condensation Positive Regulation Of Viral Genome Replication Pericentric Heterochromatin Negative Regulation Of Gene Expression, Epigenetic Chromosome, Telomeric Region Chromosome Condensation Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Gene Expression Protein Domain Specific Binding RNA Binding Nuclear Inner Membrane Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Site Of DNA Damage Heterochromatin Regulation Of Macromolecule Biosynthetic Process Protein Localization To Lysosome Positive Regulation Of Viral Process Epigenetic Regulation Of Gene Expression Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Gene Expression Structural Constituent Of Nuclear Lamina Negative Regulation Of Viral Process Regulation Of Viral Genome Replication Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Protein Localization To Vacuole Myoblast Fusion Involved In Skeletal Muscle Regeneration Nucleus Organization Chromosome Organization Protein Kinase C Inhibitor Activity Chromatin Lock Complex Regulation Of Macromolecule Metabolic Process Actin Cap Regulation Of T Cell Mediated Immunity Mitotic Chromosome Movement Towards Spindle Pole Ribosomal Protein Import Into Nucleus RNA Import Into Nucleus RNA Splicing Nuclear Speck Organization Senescence-associated Heterochromatin Focus	None