SFTPD and SFTPA1

Number of citations of the paper that reports this interaction (PubMedID 10101009)
0

Data Source:
BioGRID (biochemical)

		SFTPD	SFTPA1
Description		surfactant protein D	surfactant protein A1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Cytoplasm Lysosome Multivesicular Body Endoplasmic Reticulum Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle	Extracellular Region Collagen Trimer Extracellular Space Multivesicular Body Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle
	Molecular Function	Protein Binding Carbohydrate Binding Identical Protein Binding	Lipid Transporter Activity Protein Binding Carbohydrate Binding
	Biological Process	Regulation Of Cytokine Production Immune System Process Regulation Of Immune System Process Receptor-mediated Endocytosis Respiratory Gaseous Exchange By Respiratory System Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Surfactant Homeostasis Innate Immune Response Macrophage Chemotaxis Lung Alveolus Development Positive Regulation Of Phagocytosis Reactive Oxygen Species Metabolic Process	Lipid Transport Respiratory Gaseous Exchange By Respiratory System Opsonization
Pathways		Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses	Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor TLR1:TLR2 Cascade Signal regulatory protein family interactions Surfactant metabolism Regulation of TLR by endogenous ligand Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs		Beta-D-Glucose	2-(N-morpholino)ethanesulfonic acid
Diseases
GWAS		Chronic obstructive pulmonary disease ( 28166215 30804561 33909500) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Lung function (FEV1/FVC) ( 30804560) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		3 interacting genes: DCN DMBT1 MFAP4	2 interacting genes: DMBT1 PRDX6
Entrez ID		6441	653509
HPRD ID		01522	19256
Ensembl ID		ENSG00000133661	ENSG00000122852
Uniprot IDs		P35247	B4DNP6 K4N2H0 Q8IWL2
PDB IDs		1B08 1M7L 1PW9 1PWB 2GGU 2GGX 2ORJ 2ORK 2OS9 2RIA 2RIB 2RIC 2RID 2RIE 3DBZ 3G81 3G83 3G84 3IKN 3IKP 3IKQ 3IKR 4E52 4M17 4M18 5OXR 5OXS
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Matrix Extracellular Region Extracellular Matrix Binding	Zymogen Binding Reactive Oxygen Species Metabolic Process Receptor-mediated Endocytosis Defense Response To Bacterium Lipoteichoic Acid Binding Induction Of Bacterial Agglutination Extracellular Space 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Heparan Sulfate Binding Response To Bacterium Calcium-independent Phospholipase A2 Activity Extracellular Region Endocytosis Lysosome Scavenger Receptor Activity Zymogen Granule Membrane Defense Response To Other Organism Import Into Cell Innate Immune Response Defense Response To Symbiont Respiratory Gaseous Exchange By Respiratory System Clathrin-coated Endocytic Vesicle Macrophage Migration Surfactant Homeostasis Negative Regulation Of Interleukin-2 Production Macrophage Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Response To Stress Lipopolysaccharide Binding Pattern Recognition Receptor Activity Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis Lung Alveolus Development Multivesicular Body
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