HPN and MEGF8

Data Source: HiPPIP (Novel)

		HPN	MEGF8
Name		hepsin	multiple EGF like domains 8
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Cell-cell Junction Cell Surface Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity	Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Protein Processing Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Host-mediated Activation Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Regulation Of Biological Quality Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Morphogenesis Of An Epithelium Embryonic Heart Tube Morphogenesis Smoothened Signaling Pathway Determination Of Left/right Symmetry Heart Development Regulation Of Gene Expression Protein Ubiquitination Embryonic Limb Morphogenesis BMP Signaling Pathway Limb Morphogenesis Aorta Development Cell Migration Involved In Gastrulation Embryonic Digit Morphogenesis Negative Regulation Of Smoothened Signaling Pathway Embryonic Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Positive Regulation Of Axon Extension Involved In Axon Guidance Epiboly Involved In Gastrulation With Mouth Forming Second Limb Development Embryonic Heart Tube Left/right Pattern Formation Left/right Pattern Formation Coronary Vasculature Development Determination Of Heart Left/right Asymmetry Pharyngeal Arch Artery Morphogenesis Protein-containing Complex Assembly Determination Of Digestive Tract Left/right Asymmetry Craniofacial Suture Morphogenesis Fasciculation Of Sensory Neuron Axon Embryonic Brain Development
Pathways		MET Receptor Activation Signaling by MST1	None
Drugs		Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	None
GWAS		Appendicular lean mass ( 33097823 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum albumin levels ( 23022100 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 32154731 32203549 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: BRIP1 MEGF8	4 novel interactors: CCNE1 HPN SYT5 URI1
Interacting Genes		7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2	4 interacting genes: ATN1 CACNA1A GFI1B HOXA1
Entrez ID		3249	1954
HPRD ID		00801	10370
Ensembl ID		ENSG00000105707	ENSG00000105429
Uniprot IDs		A0A140VJK9 B7Z1L4 P05981	Q7Z7M0
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N 5CE1	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Mitochondrion Organization Endoplasmic Reticulum-autophagosome Adaptor Activity Regulation Of Release Of Cytochrome C From Mitochondria Autophagic Cell Death Substrate Localization To Autophagosome Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Mitochondrial Calcium Ion Concentration Developmental Process Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Cell Growth Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Axon Extension Involved In Axon Guidance Determination Of Heart Left/right Asymmetry Regulation Of Locomotion Determination Of Digestive Tract Left/right Asymmetry Positive Regulation Of Chemotaxis Embryonic Organ Development Fasciculation Of Sensory Neuron Axon Animal Organ Development Regulation Of Protein Kinase C Signaling Epithelial Cell Proliferation Response To Amino Acid Response To Estradiol Positive Regulation Of Cell Migration Epidermal Growth Factor Binding Positive Regulation Of Cell Motility ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Multivesicular Body, Internal Vesicle Lumen Response To Thyroxine Response To Genistein Response To Vitamin K Endopeptidase Activity Response To Hydroxyisoflavone Response To Astaxanthin Response To Phenylpropanoid Serine-type Peptidase Complex Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To L-phenylalanine Derivative Response To Thyroid Stimulating Hormone	Cochlea Morphogenesis Syntaxin Binding Neuronal Cell Body Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Cyclin E1-CDK2 Complex Negative Regulation Of RNA Biosynthetic Process Nuclear Matrix Semicircular Canal Formation Abducens Nerve Formation Optokinetic Behavior Positive Regulation Of Thyroid Hormone Generation Basement Membrane Disassembly Pilomotor Reflex Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Neuronal Dense Core Vesicle Membrane Proximal Neuron Projection Negative Regulation Of Phosphatase Activity Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of G1/S Transition Of Mitotic Cell Cycle