HPN and UPK2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HPN	UPK2
Name		hepsin	uroplakin 2
Structure			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Cell-cell Junction Cell Surface Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity	Protein Binding
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Protein Processing Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Host-mediated Activation Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Regulation Of Biological Quality Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Epithelial Cell Differentiation
Pathways		MET Receptor Activation Signaling by MST1	None
Drugs		Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	None
GWAS		Appendicular lean mass ( 33097823 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum albumin levels ( 23022100 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 32154731 32203549 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 )	Asthma ( 31959851 )
Novel Interactors		2 novel interactors: BRIP1 MEGF8	None recorded
Interacting Genes		7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2	36 interacting genes: ADGRG3 AMIGO1 ASGR2 ATP6AP2 BSCL2 BTNL9 C3orf52 CD74 CLDN7 CLEC17A CLEC7A CYB5R3 FCGR1A FCGR2A FCGRT FKBP7 FNDC9 GPA33 HPN ITM2C KASH5 KIR2DL3 KIR3DL3 LIME1 PLP1 RNF170 SLC18A1 SLC22A23 SMAGP STOML3 TMEM106C TMPRSS2 TNFSF11 TNFSF14 UPK1A ZNRF4
Entrez ID		3249	7379
HPRD ID		00801	10295
Ensembl ID		ENSG00000105707	ENSG00000110375
Uniprot IDs		A0A140VJK9 B7Z1L4 P05981	O00526
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N 5CE1	Not available
GO Terms Enriched among Interactors		Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Mitochondrion Organization Endoplasmic Reticulum-autophagosome Adaptor Activity Regulation Of Release Of Cytochrome C From Mitochondria Autophagic Cell Death Substrate Localization To Autophagosome Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Mitochondrial Calcium Ion Concentration Developmental Process Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Cell Growth Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Axon Extension Involved In Axon Guidance Determination Of Heart Left/right Asymmetry Regulation Of Locomotion Determination Of Digestive Tract Left/right Asymmetry Positive Regulation Of Chemotaxis Embryonic Organ Development Fasciculation Of Sensory Neuron Axon Animal Organ Development Regulation Of Protein Kinase C Signaling Epithelial Cell Proliferation Response To Amino Acid Response To Estradiol Positive Regulation Of Cell Migration Epidermal Growth Factor Binding Positive Regulation Of Cell Motility ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Multivesicular Body, Internal Vesicle Lumen Response To Thyroxine Response To Genistein Response To Vitamin K Endopeptidase Activity Response To Hydroxyisoflavone Response To Astaxanthin Response To Phenylpropanoid Serine-type Peptidase Complex Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To L-phenylalanine Derivative Response To Thyroid Stimulating Hormone	Membrane Plasma Membrane Immune Response-regulating Signaling Pathway External Side Of Plasma Membrane Immune System Process IgG Binding Immune Response Regulation Of Immune Response Regulation Of Immune System Process IgG Receptor Activity Regulation Of Non-canonical NF-kappaB Signal Transduction Pattern Recognition Receptor Activity Immunoglobulin Mediated Immune Response Fucose Binding B Cell Mediated Immunity Antibody-dependent Cellular Cytotoxicity Protein Binding Positive Regulation Of Immune System Process Endoplasmic Reticulum Endoplasmic Reticulum Membrane Hypersensitivity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis, Recognition Positive Regulation Of Immune Response Positive Regulation Of Viral Entry Into Host Cell Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Phagocytosis Acute Inflammatory Response To Antigenic Stimulus Immune Response-activating Signaling Pathway Regulation Of Viral Entry Into Host Cell D-mannose Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Viral Life Cycle Regulation Of Phagocytosis Positive Regulation Of Acute Inflammatory Response Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Tumor Necrosis Factor Production MHC Class II Protein Binding, Via Antigen Binding Groove NOS2-CD74 Complex Macrophage Migration Inhibitory Factor Signaling Pathway Lymphocyte Mediated Immunity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production High-affinity IgG Receptor Activity IgG Immunoglobulin Transcytosis In Epithelial Cells Mediated By FcRn Immunoglobulin Receptor Tumor Necrosis Factor Receptor Binding Eye Pigmentation Activation Of Immune Response Detection Of Yeast Detection Of Molecule Of Fungal Origin