HPN and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		HPN	GLP1R
Gene Name		hepsin	glucagon-like peptide 1 receptor
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Nuclear Membrane Neuronal Cell Body Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Calcium-activated Potassium Channel Activity Serine-type Exopeptidase Activity	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS		Serum albumin level ( 23022100)
Protein-Protein Interactions		3 interactors: F7 GLP1R HGF	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		3249	2740
HPRD ID		00801	00677
Ensembl ID		ENSG00000105707	ENSG00000112164
Uniprot IDs		B7Z1L4 P05981	P43220
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N	3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Organ Regeneration Response To Vitamin K Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Hepatocyte Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Response To Peptide Hormone Positive Regulation Of Myelination Response To Peptide Response To Organic Substance Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Hydrogen Peroxide-induced Cell Death Peptidyl-glutamic Acid Carboxylation Mesenchymal-epithelial Cell Signaling Regulation Of Body Fluid Levels Regulation Of Cell Migration Regulation Of Branching Involved In Salivary Gland Morphogenesis Wound Healing Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Signaling Regulation Of Locomotion Positive Regulation Of DNA Biosynthetic Process Regulation Of Cellular Component Movement Response To Wounding CAMP-mediated Signaling Response To Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Cell Death Positive Chemotaxis Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Positive Chemotaxis Positive Regulation Of Blood Coagulation Negative Regulation Of Mitochondrion Organization Positive Regulation Of Adenylate Cyclase Activity	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		4g accounting appointments assessments clinic collect connection continuing costs delivering distance encrypted equipment expenses maximize mobile multidisciplinary nutrition parenteral personnel plans savings scheduling setup tablet tabulate tabulates tabulation travel	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		4g accounting appointments assessments clinic collect connection continuing costs delivering distance encrypted equipment expenses maximize mobile multidisciplinary nutrition parenteral personnel plans savings scheduling setup tablet tabulate tabulates tabulation travel	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
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