HPN and HGF

Number of citations of the paper that reports this interaction (PMID 15792801)
25

Data Source:
HPRD (in vitro)

		HPN	HGF
Gene Name		hepsin	hepatocyte growth factor (hepapoietin A; scatter factor)
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Nuclear Membrane Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Calcium-activated Potassium Channel Activity Serine-type Exopeptidase Activity	Serine-type Endopeptidase Activity Protein Binding Growth Factor Activity Chemoattractant Activity Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Activation Of MAPK Activity Epithelial To Mesenchymal Transition Liver Development Platelet Degranulation Proteolysis Mitotic Nuclear Division Blood Coagulation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Organ Regeneration Positive Regulation Of Myelination Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Hepatocyte Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Myoblast Proliferation Cell Chemotaxis Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of DNA Biosynthetic Process
Pathways			Signaling by Interleukins Response to elevated platelet cytosolic Ca2+ Interleukin-7 signaling Cytokine Signaling in Immune system Platelet degranulation Platelet activation, signaling and aggregation
Drugs			O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine
Diseases
GWAS		Serum albumin level ( 23022100)
Protein-Protein Interactions		3 interactors: F7 GLP1R HGF	16 interactors: ADAMTSL4 BRCA1 CLEC3B F11 FN1 HGFAC HPN KLKB1 LCN2 MEOX2 MET PLAU SDC1 SDC2 ST14 VTN
Entrez ID		3249	3082
HPRD ID		00801	00799
Ensembl ID		ENSG00000105707	ENSG00000019991
Uniprot IDs		B7Z1L4 P05981	P14210
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N	1BHT 1GMN 1GMO 1GP9 1NK1 1SHY 1SI5 2HGF 2QJ2 3HMS 3HMT 3HN4 3MKP 3SP8 4K3J
Enriched GO Terms of Interacting Partners?		Organ Regeneration Response To Vitamin K Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Hepatocyte Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Response To Peptide Hormone Positive Regulation Of Myelination Response To Peptide Response To Organic Substance Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Hydrogen Peroxide-induced Cell Death Peptidyl-glutamic Acid Carboxylation Mesenchymal-epithelial Cell Signaling Regulation Of Body Fluid Levels Regulation Of Cell Migration Regulation Of Branching Involved In Salivary Gland Morphogenesis Wound Healing Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Signaling Regulation Of Locomotion Positive Regulation Of DNA Biosynthetic Process Regulation Of Cellular Component Movement Response To Wounding CAMP-mediated Signaling Response To Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Cell Death Positive Chemotaxis Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Positive Chemotaxis Positive Regulation Of Blood Coagulation Negative Regulation Of Mitochondrion Organization Positive Regulation Of Adenylate Cyclase Activity	Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Positive Regulation Of Protein Processing Regulation Of Blood Coagulation Regulation Of Wound Healing Wound Healing Positive Regulation Of Fibrinolysis Response To Wounding Positive Regulation Of Plasminogen Activation Positive Regulation Of Protein Metabolic Process Plasminogen Activation Protein Metabolic Process Proteolysis Extracellular Matrix Disassembly Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Tissue Development Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Processing Regulation Of Cellular Component Organization Blood Coagulation Hemostasis Fibrinolysis Detection Of Abiotic Stimulus Multicellular Organismal Development Regulation Of Protein Metabolic Process Endodermal Cell Differentiation Anatomical Structure Development Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Cell Death Regulation Of Body Fluid Levels Death Anatomical Structure Morphogenesis Response To Abiotic Stimulus Endoderm Formation Glycosaminoglycan Catabolic Process Embryo Development Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Chondroitin Sulfate Metabolic Process Response To External Stimulus Developmental Process Response To Stimulus Regulation Of Acute Inflammatory Response Acute Inflammatory Response
Tagcloud ?		4g accounting appointments assessments clinic collect connection continuing costs delivering distance encrypted equipment expenses maximize mobile multidisciplinary nutrition parenteral personnel plans savings scheduling setup tablet tabulate tabulates tabulation travel	amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions
Tagcloud (Difference) ?		4g accounting appointments assessments clinic collect connection continuing costs delivering distance encrypted equipment expenses maximize mobile multidisciplinary nutrition parenteral personnel plans savings scheduling setup tablet tabulate tabulates tabulation travel	amifostine anticancer benefits csf cytoprotective decitabine demethylating developments emerging gm granulocyte hematologic hematopoietic hgfs improvements includes infectious introduced issues keratinocyte kgf prophylactic renewed risks supportive thrombopoietin topics transfusional transfusions
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