HPN and F7

Number of citations: 0 (PubMedID 7814421)
Data Source: HPRD (in vitro)

		HPN	F7
Name		hepsin	coagulation factor VII
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Cell-cell Junction Cell Surface Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Extracellular Matrix Vesicle Serine-type Peptidase Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity	Endopeptidase Activity Serine-type Endopeptidase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Protein Processing Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Host-mediated Activation Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Regulation Of Biological Quality Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Response To Hypoxia Positive Regulation Of Leukocyte Chemotaxis Proteolysis Response To Stress Blood Coagulation Hemostasis Circadian Rhythm Response To Hormone Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Animal Organ Regeneration Response To Nutrient Levels Positive Regulation Of TOR Signaling Response To Estradiol Response To Vitamin K Response To Genistein Response To Estrogen Regulation Of Body Fluid Levels Positive Regulation Of Positive Chemotaxis Response To Growth Hormone Response To Cholesterol Response To Thyroid Hormone Response To Thyroxine Response To Thyroid Stimulating Hormone Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Astaxanthin Response To Thyrotropin-releasing Hormone
Pathways		MET Receptor Activation Signaling by MST1	BMAL1:CLOCK,NPAS2 activates circadian expression Extrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins
Drugs		Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine	IIa Recombinant Human Coagulation Factor IX (Recombinant) (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Kappadione Anti-inhibitor coagulant complex Coagulation Factor IX Human Nonacog beta pegol
GWAS		Appendicular lean mass ( 33097823 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum albumin levels ( 23022100 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 32154731 32203549 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 )	Bipolar disorder ( 31043756 ) Blood protein levels ( 30072576 ) Factor VII ( 17903294 ) Factor VII activity ( 30642921 ) Factor VII activity or levels ( 30642921 ) Factor VII levels ( 20231535 ) Prothrombin time ( 22703881 29403010 )
Interacting Genes		7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2	7 interacting genes: ALB F10 F3 F9 GGCX HPN RCHY1
Entrez ID		3249	2155
HPRD ID		00801	01965
Ensembl ID		ENSG00000105707	ENSG00000057593
Uniprot IDs		A0A140VJK9 B7Z1L4 P05981	B4DPM2 F5H8B0 P08709
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N 5CE1	1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF 4NA9 4NG9 4NGA 4X8S 4X8T 4X8U 4X8V 4YLQ 4YT6 4YT7 4Z6A 4ZMA 4ZXX 4ZXY 5I46 5L0S 5L2Y 5L2Z 5L30 5PA8 5PA9 5PAA 5PAB 5PAC 5PAE 5PAF 5PAG 5PAI 5PAJ 5PAK 5PAM 5PAN 5PAO 5PAQ 5PAR 5PAS 5PAT 5PAU 5PAV 5PAW 5PAX 5PAY 5PB0 5PB1 5PB2 5PB3 5PB4 5PB5 5PB6 5TQE 5TQF 5TQG 5U6J 8UUD
GO Terms Enriched among Interactors		Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Mitochondrion Organization Endoplasmic Reticulum-autophagosome Adaptor Activity Regulation Of Release Of Cytochrome C From Mitochondria Autophagic Cell Death Substrate Localization To Autophagosome Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Mitochondrial Calcium Ion Concentration Developmental Process Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Cell Growth Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Axon Extension Involved In Axon Guidance Determination Of Heart Left/right Asymmetry Regulation Of Locomotion Determination Of Digestive Tract Left/right Asymmetry Positive Regulation Of Chemotaxis Embryonic Organ Development Fasciculation Of Sensory Neuron Axon Animal Organ Development Regulation Of Protein Kinase C Signaling Epithelial Cell Proliferation Response To Amino Acid Response To Estradiol Positive Regulation Of Cell Migration Epidermal Growth Factor Binding Positive Regulation Of Cell Motility ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Multivesicular Body, Internal Vesicle Lumen Response To Thyroxine Response To Genistein Response To Vitamin K Endopeptidase Activity Response To Hydroxyisoflavone Response To Astaxanthin Response To Phenylpropanoid Serine-type Peptidase Complex Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To L-phenylalanine Derivative Response To Thyroid Stimulating Hormone	Coagulation Blood Coagulation Hemostasis Serine-type Endopeptidase Activity Endoplasmic Reticulum Lumen Regulation Of Body Fluid Levels Protein Maturation Serine-type Peptidase Activity Proteolysis Protein Processing Regulation Of Biological Quality Protein Metabolic Process Activation Of Plasma Proteins Involved In Acute Inflammatory Response Gamma-glutamyl Carboxylase Activity Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Activation Of Blood Coagulation Via Clotting Cascade Positive Regulation Of TOR Signaling Serine-type Peptidase Complex Peptidase Activity Golgi Lumen Vitamin Binding Negative Regulation Of Bone Development Phospholipid Binding Negative Regulation Of Testosterone Biosynthetic Process Basement Membrane Disassembly Pilomotor Reflex Extracellular Space Regulation Of TOR Signaling Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid Hormone Generation Serine-type Exopeptidase Activity Error-free Translesion Synthesis Positive Regulation Of Epithelial Cell Proliferation Macromolecule Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Positive Regulation Of Proteolysis Negative Regulation Of Mitochondrial Depolarization Positive Regulation Of Plasminogen Activation Regulation Of Bone Development Positive Regulation Of Hepatocyte Proliferation Toxic Substance Binding Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Vitamin K Metabolic Process Extracellular Region Regulation Of Hepatocyte Proliferation Regulation Of Plasminogen Activation