HPN and F7

Number of citations of the paper that reports this interaction (PMID 7814421)
14

Data Source:
HPRD (in vitro)

		HPN	F7
Gene Name		hepsin	coagulation factor VII (serum prothrombin conversion accelerator)
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Nuclear Membrane Neuronal Cell Body Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Vesicle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Calcium-activated Potassium Channel Activity Serine-type Exopeptidase Activity	Glycoprotein Binding Serine-type Endopeptidase Activity Receptor Binding Calcium Ion Binding Protein Binding Serine-type Peptidase Activity
	Biological Process	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Positive Regulation Of Cell Growth Basement Membrane Disassembly Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation	Positive Regulation Of Leukocyte Chemotaxis Proteolysis Blood Coagulation Blood Coagulation, Extrinsic Pathway Circadian Rhythm Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-glutamic Acid Carboxylation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Organ Regeneration Response To Vitamin K Response To Estrogen Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling Response To Growth Hormone
Pathways			Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Post-translational protein modification Extrinsic Pathway Removal of aminoterminal propeptides from gamma-carboxylated proteins Formation of Fibrin Clot (Clotting Cascade) Gamma-carboxylation of protein precursors BMAL1:CLOCK,NPAS2 activates circadian gene expression Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Coagulation factor VIIa Coagulation Factor IX Menadione (2R)-({4-[AMINO(IMINO)METHYL]PHENYL}AMINO){5-ETHOXY-2-FLUORO-3-[(3R)-TETRAHYDROFURAN-3-YLOXY]PHENYL}ACETICACID 3-({1-[3-CARBAMIMIDOYL-1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-PROPYLCARBAMOYL]-2-METHYL-BUTYLSULFAMOYL}-METHYL)-BENZOIC ACID 2-[2-ETHANESULFONYLAMINO-3-(5-PROPOXY-1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIMIDOYL-BENZYLAMIDE) 2-[2-ETHANESULFONYLAMINO-3-(1H-INDOL-3-YL)-PROPIONYLAMINO]-PENTANEDIOIC ACID 5-AMIDE 1-(4-CARBAMIM IDOYL-BENZYLAMIDE) N-[1-(4-CARBAMIMIDOYL-BENZYLCARBAMOYL)-3-METHYLSULFANYL-PROPYL]-3-HYDROXY-2-PROPOXYAMINO-BUTYRAMID 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2\'-HYDROXY-3\'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID) {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3\'-NITRO-BIPHENYL-3-YL]-ACETIC ACID
Diseases
GWAS		Serum albumin level ( 23022100)	Factor VII ( 17903294) Prothrombin time ( 22703881)
Protein-Protein Interactions		3 interactors: F7 GLP1R HGF	7 interactors: ALB F10 F3 F9 GGCX HPN RCHY1
Entrez ID		3249	2155
HPRD ID		00801	01965
Ensembl ID		ENSG00000105707	ENSG00000057593
Uniprot IDs		B7Z1L4 P05981	B4DPM2 P08709
PDB IDs		1O5E 1O5F 1P57 1Z8G 3T2N	1BF9 1CVW 1DAN 1DVA 1F7E 1F7M 1FAK 1FF7 1FFM 1J9C 1JBU 1KLI 1KLJ 1NL8 1O5D 1QFK 1W0Y 1W2K 1W7X 1W8B 1WQV 1WSS 1WTG 1WUN 1WV7 1YGC 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2BZ6 2C4F 2EC9 2F9B 2FIR 2FLB 2FLR 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4ISH 4ISI 4JYU 4JYV 4JZD 4JZE 4JZF
Enriched GO Terms of Interacting Partners?		Organ Regeneration Response To Vitamin K Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Myoblast Proliferation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Hepatocyte Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling Response To Peptide Hormone Positive Regulation Of Myelination Response To Peptide Response To Organic Substance Positive Regulation Of Neuron Projection Regeneration Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Hydrogen Peroxide-induced Cell Death Peptidyl-glutamic Acid Carboxylation Mesenchymal-epithelial Cell Signaling Regulation Of Body Fluid Levels Regulation Of Cell Migration Regulation Of Branching Involved In Salivary Gland Morphogenesis Wound Healing Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Signaling Regulation Of Locomotion Positive Regulation Of DNA Biosynthetic Process Regulation Of Cellular Component Movement Response To Wounding CAMP-mediated Signaling Response To Stress Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Oxidative Stress-induced Cell Death Positive Chemotaxis Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Positive Chemotaxis Positive Regulation Of Blood Coagulation Negative Regulation Of Mitochondrion Organization Positive Regulation Of Adenylate Cyclase Activity	Blood Coagulation, Extrinsic Pathway Peptidyl-glutamic Acid Carboxylation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Blood Coagulation, Intrinsic Pathway Protein Activation Cascade Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Kinase B Signaling Activation Of Plasma Proteins Involved In Acute Inflammatory Response Proteolysis Regulation Of Protein Kinase B Signaling Maintenance Of Mitochondrion Location Activation Of Blood Coagulation Via Clotting Cascade Basement Membrane Disassembly Positive Regulation Of Behavior Positive Regulation Of Epithelial Cell Proliferation Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Thyroid Hormone Generation Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Stress Pilomotor Reflex Regulation Of Behavior Positive Regulation Of Plasminogen Activation Positive Regulation Of Hepatocyte Proliferation Regulation Of Thyroid Hormone Generation Peptidyl-amino Acid Modification Negative Regulation Of Alkaline Phosphatase Activity Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation By Host Of Viral Transcription Regulation Of Epithelial Cell Proliferation Positive Regulation Of Proteolysis Regulation Of Hepatocyte Proliferation Sodium-independent Organic Anion Transport Positive Regulation Of Cell Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of Cell Motility Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Response To Thyroid Hormone Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Epithelial Cell Polarity Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Circadian Rhythm
Tagcloud ?		4g accounting appointments assessments clinic collect connection continuing costs delivering distance encrypted equipment expenses maximize mobile multidisciplinary nutrition parenteral personnel plans savings scheduling setup tablet tabulate tabulates tabulation travel	4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin
Tagcloud (Difference) ?		4g accounting appointments assessments clinic collect connection continuing costs delivering distance encrypted equipment expenses maximize mobile multidisciplinary nutrition parenteral personnel plans savings scheduling setup tablet tabulate tabulates tabulation travel	4e autoregulation betatc6 biosynthesis cap dependently dephosphorylation exert exogenous glucose immunosuppressant incubation insulin interacting islet islets latter mediate phas phosphatidylinositol phosphodiesterase rapamycin secreted serve stimulate stimulates theophylline translation wortmannin
Tagcloud (Intersection) ?