SIL1 and SETD7

		SIL1	SETD7
Description		SIL1 nucleotide exchange factor	SET domain containing 7, histone lysine methyltransferase
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Unfolded Protein Binding	P53 Binding Chromatin Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity
	Biological Process	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Protein Transport	Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Response To Ethanol Positive Regulation Of DNA-templated Transcription Heterochromatin Organization Response To Alcohol
Pathways			PKMTs methylate histone lysines
Drugs			S-adenosyl-L-homocysteine
Diseases
GWAS		Appendicular lean mass ( 33097823) Malaria ( 31844061)	Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Ferritin levels ( 33491795) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)
Interacting Genes		6 interacting genes: CCND3 FEM1C HSPA5 SGTB SMAD9 UBQLN1	32 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 OGT OTUB1 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21 UBC
Entrez ID		64374	80854
HPRD ID		12150	16226
Ensembl ID		ENSG00000120725	ENSG00000145391
Uniprot IDs		A0A0S2Z6B4 Q9H173	B5MCZ8 D6RJA0 Q8WTS6
PDB IDs		6LBN 6LEY 8PQL 8Q7R	1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Folding In Endoplasmic Reticulum Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Store-operated Calcium Channel Activity Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Cerebellum Structural Organization Regulation Of Endoribonuclease Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate TRC Complex Flavin Adenine Dinucleotide Biosynthetic Process Protein-folding Chaperone Binding Positive Regulation Of Protein Modification Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Synapse Assembly Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Unfolded Protein Binding Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Riboflavin Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity	Chromatin Organization Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Remodeling Protein-DNA Complex Assembly Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Promoter-specific Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Transcription Chromatin DNA Binding Regulation Of Cell Differentiation Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction
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