SIL1 and RFK

		SIL1	RFK
Description		SIL1 nucleotide exchange factor	riboflavin kinase
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Unfolded Protein Binding	Nucleotide Binding Protein Binding ATP Binding Riboflavin Kinase Activity Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Protein Transport	Riboflavin Metabolic Process Apoptotic Process Riboflavin Biosynthetic Process FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Flavin Adenine Dinucleotide Biosynthetic Process Reactive Oxygen Species Metabolic Process
Pathways			Vitamin B2 (riboflavin) metabolism
Drugs			Riboflavin Flavin mononucleotide
Diseases
GWAS		Appendicular lean mass ( 33097823) Malaria ( 31844061)	Metabolite levels ( 23823483) Multiple sclerosis (age of onset) ( 19010793)
Interacting Genes		6 interacting genes: CCND3 FEM1C HSPA5 SGTB SMAD9 UBQLN1	4 interacting genes: CNTLN CREBBP DNAJB9 RAB1A
Entrez ID		64374	55312
HPRD ID		12150	17969
Ensembl ID		ENSG00000120725	ENSG00000135002
Uniprot IDs		A0A0S2Z6B4 Q9H173	B2RDZ2 Q969G6
PDB IDs		6LBN 6LEY 8PQL 8Q7R	1NB0 1NB9 1P4M 1Q9S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Folding In Endoplasmic Reticulum Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Store-operated Calcium Channel Activity Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Cerebellum Structural Organization Regulation Of Endoribonuclease Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate TRC Complex Flavin Adenine Dinucleotide Biosynthetic Process Protein-folding Chaperone Binding Positive Regulation Of Protein Modification Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Synapse Assembly Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Unfolded Protein Binding Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Riboflavin Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity
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