SIL1 and GHRL

		SIL1	GHRL
Description		SIL1 nucleotide exchange factor	ghrelin and obestatin prepropeptide
Image
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Axon Secretory Granule Lumen Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Neuronal Dense Core Vesicle Lumen
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding Unfolded Protein Binding	G Protein-coupled Receptor Binding Hormone Activity Protein Binding Growth Hormone-releasing Hormone Activity Protein Tyrosine Kinase Activator Activity Ghrelin Receptor Binding
	Biological Process	Protein Folding Cotranslational Protein Targeting To Membrane Intracellular Protein Transport Protein Transport	Gastric Acid Secretion Negative Regulation Of Endothelial Cell Proliferation G Protein-coupled Receptor Internalization Glucose Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Synapse Assembly Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Dendrite Development Negative Regulation Of Angiogenesis Growth Hormone Secretion Response To Nutrient Levels Positive Regulation Of Insulin Secretion Regulation Of Response To Food Positive Regulation Of Response To Food Positive Regulation Of Appetite Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Growth Rate Negative Regulation Of Locomotion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Negative Regulation Of Apoptotic Process Cortisol Secretion Positive Regulation Of MAPK Cascade Response To Estrogen Positive Regulation Of Growth Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Cartilage Development Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Response To Electrical Stimulus Positive Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Growth Hormone Receptor Signaling Pathway Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Development Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Positive Regulation Of Adipose Tissue Development Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Positive Regulation Of Gastric Mucosal Blood Circulation Positive Regulation Of Small Intestine Smooth Muscle Contraction Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Feeding Behavior
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Malaria ( 31844061)	Autism spectrum disorder or schizophrenia ( 28540026) ghrelin levels ( 33852427)
Interacting Genes		6 interacting genes: CCND3 FEM1C HSPA5 SGTB SMAD9 UBQLN1	9 interacting genes: ACE2 AGRP GHRHR GHSR LEP MLNR NPY UBQLN1 UBQLN2
Entrez ID		64374	51738
HPRD ID		12150	05638
Ensembl ID		ENSG00000120725	ENSG00000157017
Uniprot IDs		A0A0S2Z6B4 Q9H173	Q9UBU3
PDB IDs		6LBN 6LEY 8PQL 8Q7R	6H3E 7F9Y 7NA7 7W2Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Response To Stress Regulation Of Protein Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein Folding In Endoplasmic Reticulum Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Store-operated Calcium Channel Activity Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation FMN Biosynthetic Process Positive Regulation Of NAD(P)H Oxidase Activity Riboflavin Kinase Activity Riboflavin Biosynthetic Process Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex Cerebellum Structural Organization Regulation Of Endoribonuclease Activity Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate TRC Complex Flavin Adenine Dinucleotide Biosynthetic Process Protein-folding Chaperone Binding Positive Regulation Of Protein Modification Process Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Synapse Assembly Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Cell Cycle Phase Transition Unfolded Protein Binding Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Riboflavin Metabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity	Adult Feeding Behavior Feeding Behavior Positive Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Behavior Regulation Of Response To Food Regulation Of Appetite Regulation Of Feeding Behavior Growth Hormone-releasing Hormone Receptor Activity Regulation Of Response To Nutrient Levels Adult Behavior Positive Regulation Of Eating Behavior Positive Regulation Of Response To Food Positive Regulation Of Appetite Response To Insulin Growth Hormone Secretion Regulation Of Eating Behavior Peptide Hormone Secretion Regulation Of Transport Peptide Secretion Regulation Of Amine Transport Hormone Secretion Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Appetite Response To Peptide Hormone Regulation Of Growth Hormone Secretion Cellular Response To Insulin Stimulus Peptide Transport Hormone Transport Hormone Binding Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Amide Transport Regulation Of Defense Response Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of ERAD Pathway Signal Release Positive Regulation Of Developmental Growth Photoperiodism Regulation Of Blood Pressure Neuropeptide Hormone Activity Cellular Response To Peptide Hormone Stimulus Eating Behavior Maternal Process Involved In Female Pregnancy Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Determination Of Adult Lifespan Positive Regulation Of Multicellular Organismal Process
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