NSD1 and RXRA

Number of citations of the paper that reports this interaction (PMID 9628876)
51

Data Source:
HPRD (in vitro)

		NSD1	RXRA
Gene Name		nuclear receptor binding SET domain protein 1	retinoid X receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nuclear Chromatin Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Vitamin D Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoic Acid-responsive Element Binding Protein Heterodimerization Activity Vitamin D Response Element Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Maternal Placenta Development Transcription Initiation From RNA Polymerase II Promoter Vitamin Metabolic Process Embryo Implantation Cholesterol Metabolic Process Gene Expression Modulation By Virus Of Host Morphology Or Physiology Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway Camera-type Eye Development Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Retinoic Acid Receptor Signaling Pathway Protein Homotetramerization Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway Metabolic disorders of biological oxidation enzymes Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Generic Transcription Pathway Endogenous sterols Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Signaling by Retinoic Acid Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Synthesis of bile acids and bile salts via 27-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Activation of gene expression by SREBF (SREBP) The citric acid (TCA) cycle and respiratory electron transport Transcriptional activation of mitochondrial biogenesis PPARA activates gene expression Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Organelle biogenesis and maintenance Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism and Citric Acid (TCA) cycle Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Cytochrome P450 - arranged by substrate type Transcriptional regulation of white adipocyte differentiation Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) REV-ERBA represses gene expression Defective CYP1B1 causes Glaucoma Mitochondrial biogenesis Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs			Adapalene Bexarotene Acitretin Alitretinoin Etodolac Etretinate (5BETA)-PREGNANE-3,20-DIONE 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID tributylstannanyl
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Central corneal thickness ( 22814818 23493294) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intelligence ( 22449649)
Protein-Protein Interactions		27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	113 interactors: ACVR1 ACVR1B ALOX15B ARID5A ARNTL BCL3 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNTTIP2 EDF1 ESR1 ESR2 FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBQLN4 VDR ZBTB16 ZNHIT3
Entrez ID		64324	6256
HPRD ID		09455	01577
Ensembl ID		ENSG00000165671
Uniprot IDs		Q96L73 Q96MN8	F1D8Q5 P19793 Q6P3U7
PDB IDs		3OOI	1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4J5W 4J5X
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development	Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Lipid Cellular Response To Steroid Hormone Stimulus Response To Hormone Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Response To Lipid Cellular Response To Organic Substance Response To Organic Substance Cellular Metabolic Process
Tagcloud ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 hspa5 lies linkage loci map mmu2 nf1 occupy painting places probable syntenic telomeric thirds
Tagcloud (Difference) ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 hspa5 lies linkage loci map mmu2 nf1 occupy painting places probable syntenic telomeric thirds
Tagcloud (Intersection) ?