NSD1 and NR2E1

Number of citations: 67 (PubMedID 23975195)
Data Source: BioGRID (two hybrid)

		NSD1	NR2E1
Name		nuclear receptor binding SET domain protein 1	nuclear receptor subfamily 2 group E member 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Nuclear Retinoic Acid Receptor Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Histone H3K36 Methyltransferase Activity Nuclear Androgen Receptor Binding Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of DNA-templated Transcription Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Behavioral Fear Response Positive Regulation Of Neuroblast Proliferation Aggressive Behavior Regulation Of DNA-templated Transcription Apoptotic Process Nervous System Development Neuroblast Proliferation Brain Development Visual Perception Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Central Nervous System Neuron Differentiation Anterior Commissure Morphogenesis Cerebral Cortex Development Cell Differentiation Extracellular Matrix Organization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Social Behavior Camera-type Eye Development Negative Regulation Of Apoptotic Process Astrocyte Cell Migration Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Regulation Of Cellular Component Organization Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Neural Precursor Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation
Pathways		PKMTs methylate histone lysines	Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Diseases		Sotos syndrome and Weaver syndrome Beckwith-Wiedemann syndrome	None
GWAS		Activated partial thromboplastin time ( 22703881 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Circulating fibroblast growth factor 23 levels ( 30217807 ) Height ( 25282103 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Lymphocyte count ( 32888494 ) Narrowest width of the femoral neck ( 30888730 ) Neutrophil count ( 32888494 ) Nonsyndromic cleft lip ( 31609978 ) Urate levels ( 31578528 ) Urate levels in lean individuals ( 25811787 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for body mass index ( 28448500 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Interacting Genes		37 interacting genes: AGR2 AR ATRX CCDC125 CYSRT1 ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4C1 H4C16 HNF4G KRTAP6-2 MDFI NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 USP7 VDR ZNF496	6 interacting genes: ATN1 DNMT3L ERBIN KDM1A NSD1 RERE
Entrez ID		64324	7101
HPRD ID		09455	07230
Ensembl ID		ENSG00000165671	ENSG00000112333
Uniprot IDs		A0A8I5QJP2 Q96L73 Q96MN8	B6ZGT9 Q9Y466
PDB IDs		3OOI 6KQP 6KQQ 8C5L	4XAJ
GO Terms Enriched among Interactors		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression Nuclear Steroid Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Retinoic Acid Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Transcription Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Metabolic Process Nucleosome Assembly Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Biosynthetic Process Nucleosome Organization Regulation Of Metabolic Process Structural Constituent Of Chromatin Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Estrogen Response Element Binding Positive Regulation Of RNA Metabolic Process	Transcription Corepressor Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Nuclear Androgen Receptor Binding Regulation Of Chromatin Organization Chromatin Remodeling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Transcription Coactivator Activity Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Post-embryonic Development Regulation Of Nucleobase-containing Compound Metabolic Process Cerebellar Purkinje Cell Layer Maturation Chromatin Binding Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Basal Protein Localization Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Radial Glia Guided Migration Of Purkinje Cell Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Epigenetic Programing Of Female Pronucleus ErbB-2 Class Receptor Binding Positive Regulation Of Biosynthetic Process Protein Demethylase Activity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Histone H3K36 Dimethyltransferase Activity Establishment Or Maintenance Of Cell Polarity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Branching Morphogenesis Of A Nerve Platelet Dense Granule Membrane Response To Fungicide MRF Binding Guanine Metabolic Process Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Macromolecule Biosynthetic Process Methylation