NSD1 and TNFRSF21

Number of citations of the paper that reports this interaction (PMID 15623156)
0

Data Source:
BioGRID (pull down)

		NSD1	TNFRSF21
Gene Name		nuclear receptor binding SET domain protein 1	tumor necrosis factor receptor superfamily, member 21
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Plasma Membrane Integral Component Of Plasma Membrane Axon Intrinsic Component Of Plasma Membrane
	Molecular Function	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated	B Cell Apoptotic Process Adaptive Immune Response Apoptotic Process Humoral Immune Response Negative Regulation Of B Cell Proliferation Negative Regulation Of Myelination Negative Regulation Of T Cell Proliferation Myelination Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Oligodendrocyte Differentiation T Cell Receptor Signaling Pathway Neuron Apoptotic Process Cellular Response To Tumor Necrosis Factor Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-5 Secretion Negative Regulation Of Interleukin-13 Secretion Negative Regulation Of Interleukin-10 Secretion
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Panic disorder ( 19165232)
Protein-Protein Interactions		27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	6 interactors: CLIP3 MATR3 NSD1 STX11 TRADD WASH2P
Entrez ID		64324	27242
HPRD ID		09455	05759
Ensembl ID		ENSG00000165671	ENSG00000146072
Uniprot IDs		Q96L73 Q96MN8	O75509
PDB IDs		3OOI	2DBH 3QO4 3U3P 3U3Q 3U3S 3U3T 3U3V
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development	Peptidyl-L-cysteine S-palmitoylation Neutrophil Degranulation Cytotoxic T Cell Degranulation Chaperone-mediated Protein Transport Neutrophil Activation Involved In Immune Response Regulation Of Protein Complex Assembly Histone H3-K36 Methylation Natural Killer Cell Degranulation Positive Regulation Of Hair Follicle Development Synaptic Vesicle Fusion To Presynaptic Membrane T Cell Mediated Cytotoxicity Negative Regulation Of Microtubule Polymerization Histone H4-K20 Methylation Regulation Of Hair Follicle Development Regulation Of Cytoskeleton Organization Neutrophil Mediated Immunity Neutrophil Activation Regulation Of Hair Cycle Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Natural Killer Cell Activation Involved In Immune Response Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Localization To Plasma Membrane Natural Killer Cell Mediated Immunity Membrane Biogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Microtubule Polymerization Protein Palmitoylation Positive Regulation Of Cell Death Positive Regulation Of Epidermis Development T Cell Mediated Immunity Leukocyte Mediated Cytotoxicity
Tagcloud ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	87mg ags alteration arrayed bad bcl2 bcl2l11 bfar bnip3l casp7 cidea cideb combat endows exceptions irrelevant oct4 oct4b1 pluripotent sirnas spliced stream tenfold tp73 traf3 uncovering
Tagcloud (Difference) ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	87mg ags alteration arrayed bad bcl2 bcl2l11 bfar bnip3l casp7 cidea cideb combat endows exceptions irrelevant oct4 oct4b1 pluripotent sirnas spliced stream tenfold tp73 traf3 uncovering
Tagcloud (Intersection) ?