RXRA and JAZF1

Number of citations of the paper that reports this interaction (PubMedID 15302918)
39

Data Source:
BioGRID (two hybrid)

		RXRA	JAZF1
Description		retinoid X receptor alpha	JAZF zinc finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Receptor Complex RNA Polymerase II Transcription Regulator Complex	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding Retinoic Acid Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Peptide Binding Identical Protein Binding Nuclear Vitamin D Receptor Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding DNA Binding Domain Binding LBD Domain Binding Vitamin D Response Element Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Nervous System Development Hormone-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Cell Differentiation Monocyte Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Lipid Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Cell Maturation Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Low-density Lipoprotein Particle Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Positive Regulation Of Lipoprotein Transport	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine shuttle Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Cytoprotection by HMOX1 Heme signaling TGFBR3 expression MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		alpha-Linolenic acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid EVT-101 3,20-Pregnanedione 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID Tributyltin
Diseases			Type II diabetes mellitus
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Blood pressure ( 24954895) Central corneal thickness ( 22814818 23493294 28171582 29760442 30894546 31798171) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) HDL cholesterol levels in HIV infection ( 33109212) Intelligence ( 22449649) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	A body shape index ( 34021172) Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Alcoholic chronic pancreatitis ( 28754779) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Appendicular lean mass ( 33097823) Asthma ( 31959851 31619474 30929738 32296059 34103634 31361310) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index and type 2 diabetes (pairwise) ( 33619380) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Eosinophilic esophagitis ( 29904099) Fasting glucose ( 34059833) FEV1 ( 30804560) Free thyroxine concentration ( 24722205) Gout ( 22179738) Heel bone mineral density ( 28869591 30598549) Height ( 28552196 18952825 19343178 20881960 23563607 25282103) Hip circumference adjusted for BMI ( 34021172 25673412) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Prostate cancer ( 34012061 31562322 18264096) Prostate-specific antigen levels ( 28139693) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 26606652 28714469 19838195 26502338) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systolic blood pressure ( 30224653 30578418) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Triglyceride levels ( 32203549) Type 1 diabetes ( 34127860) Type 2 diabetes ( 32499647 30054458 18372903 30297969 29358691 28869590 20581827 22885922 24509480 26961502 31118516 27189021) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172 28448500 28552196) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		119 interacting genes: ACVR1 ACVR1B ALOX15B ARID5A BCL3 BMAL1 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNMT3L DNTTIP2 EDF1 ESR1 ESRRA FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A KLF5 MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A1 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCB1 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBE2I UBQLN4 UBR5 VDR ZBTB16 ZNHIT3	4 interacting genes: FAM9B NR2C2 PPARG RXRA
Entrez ID		6256	221895
HPRD ID		01577	09373
Ensembl ID		ENSG00000186350	ENSG00000153814
Uniprot IDs		A0A5F9ZHH6 F1D8Q5 P19793 Q6P3U7	Q86VZ6
PDB IDs		1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6JNO 6JNR 6L6K 6LB4 6LB5 6LB6 6SJM 6STI 6XWG 6XWH 7A77 7B88 7B9O 7BK4 7CFO 7NKE 7UW2 7UW4 8HBM 8PP0
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Regulation Of Primary Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Nuclear Receptor Activity Nuclear Retinoid X Receptor Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Sequence-specific DNA Binding Nuclear Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-templated Transcription Transcription Coactivator Activity Transcription By RNA Polymerase II Nuclear Thyroid Hormone Receptor Binding Transcription Regulator Complex Nuclear Retinoic Acid Receptor Binding Intracellular Signal Transduction Retinoic Acid Receptor Signaling Pathway Cellular Response To Hormone Stimulus	Nuclear Receptor Activity DNA Binding Domain Binding Positive Regulation Of Lipoprotein Transport LBD Domain Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Monocyte Differentiation Intracellular Receptor Signaling Pathway Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cholesterol Efflux Cellular Response To Low-density Lipoprotein Particle Stimulus Peptide Binding Positive Regulation Of Cholesterol Transport Cellular Response To Lipoprotein Particle Stimulus Transcription Coregulator Binding Regulation Of Cholesterol Efflux MRNA Transcription By RNA Polymerase II Sequence-specific DNA Binding MRNA Transcription Regulation Of Cholesterol Transport Positive Regulation Of Lipid Transport Nuclear Receptor-mediated Signaling Pathway DNA-binding Transcription Factor Activity Double-stranded DNA Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Myeloid Leukocyte Differentiation Cell Maturation Hormone-mediated Signaling Pathway Positive Regulation Of Adiponectin Secretion Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Receptor Complex Cellular Developmental Process Developmental Maturation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Prostaglandin Receptor Activity Negative Regulation Of Mitochondrial Fission Positive Regulation Of Protein Transport Myeloid Cell Differentiation Arachidonate Binding Transcription Cis-regulatory Region Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process
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