RXRA and TAF11

Number of citations of the paper that reports this interaction (PMID 8670810)
25

Data Source:
HPRD (in vitro)

		RXRA	TAF11
Gene Name		retinoid X receptor, alpha	TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
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Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Receptor Complex RNA Polymerase II Transcription Factor Complex	Nucleoplasm Transcription Factor TFIID Complex Golgi Apparatus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Transcription Coactivator Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity 9-cis Retinoic Acid Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Vitamin D Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoic Acid-responsive Element Binding Protein Heterodimerization Activity Vitamin D Response Element Binding	DNA Binding Transcription Coactivator Activity Protein Binding Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Maternal Placenta Development Transcription Initiation From RNA Polymerase II Promoter Vitamin Metabolic Process Embryo Implantation Cholesterol Metabolic Process Gene Expression Modulation By Virus Of Host Morphology Or Physiology Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway Camera-type Eye Development Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation By Iron Retinoic Acid Receptor Signaling Pathway Protein Homotetramerization Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Differentiation Transmembrane Transport Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation By Host Of Viral Transcription
Pathways		Bile acid and bile salt metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway Metabolic disorders of biological oxidation enzymes Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Generic Transcription Pathway Endogenous sterols Synthesis of bile acids and bile salts Orphan transporters Defective FMO3 causes Trimethylaminuria (TMAU) Signaling by Retinoic Acid Recycling of bile acids and salts Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Synthesis of bile acids and bile salts via 27-hydroxycholesterol Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Activation of gene expression by SREBF (SREBP) The citric acid (TCA) cycle and respiratory electron transport Transcriptional activation of mitochondrial biogenesis PPARA activates gene expression Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Organelle biogenesis and maintenance Import of palmitoyl-CoA into the mitochondrial matrix Pyruvate metabolism and Citric Acid (TCA) cycle Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Cytochrome P450 - arranged by substrate type Transcriptional regulation of white adipocyte differentiation Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Fatty acid, triacylglycerol, and ketone body metabolism Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) REV-ERBA represses gene expression Defective CYP1B1 causes Glaucoma Mitochondrial biogenesis Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BMAL1:CLOCK,NPAS2 activates circadian gene expression	RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome
Drugs		Adapalene Bexarotene Acitretin Alitretinoin Etodolac Etretinate (5BETA)-PREGNANE-3,20-DIONE 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID tributylstannanyl
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Central corneal thickness ( 22814818 23493294) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intelligence ( 22449649)
Protein-Protein Interactions		113 interactors: ACVR1 ACVR1B ALOX15B ARID5A ARNTL BCL3 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNTTIP2 EDF1 ESR1 ESR2 FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBQLN4 VDR ZBTB16 ZNHIT3	28 interactors: APP APPBP2 CPSF1 GTF2B GTF2E1 GTF2F1 HIST3H3 LZTR1 NFYA NFYB NFYC RELA RXRA RXRB TAF1 TAF10 TAF12 TAF13 TAF2 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBP TRIM24 VDR
Entrez ID		6256	6882
HPRD ID		01577	15980
Ensembl ID			ENSG00000064995
Uniprot IDs		F1D8Q5 P19793 Q6P3U7	Q15544
PDB IDs		1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1LBD 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4J5W 4J5X	1BH8 1BH9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Lipid Cellular Response To Steroid Hormone Stimulus Response To Hormone Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Cellular Response To Organic Cyclic Compound Response To Lipid Cellular Response To Organic Substance Response To Organic Substance Cellular Metabolic Process	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Viral Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Metabolic Process Peptidyl-lysine Modification Regulation Of Cellular Process Maternal Placenta Development Histone H3 Acetylation Cellular Response To Steroid Hormone Stimulus Histone Modification Cellular Response To Organic Cyclic Compound Maternal Process Involved In Female Pregnancy Cellular Response To Lipid
Tagcloud ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 hspa5 lies linkage loci map mmu2 nf1 occupy painting places probable syntenic telomeric thirds	autosomal copy ct47 d4z4 dystrophy euchromatic extreme facioscapulohumeral governed h3k27me3 h3k9me3 heterochromatic heterochromatinization hypermethylation leaky lymphoblastoid macrosatellite msrs muscular organized originating prr20 repressive testis trimethylated trimethylation understudied xq24 zav
Tagcloud (Difference) ?		17q 22cm canine centromeric cfa9 correspond cosmid cryba1 distal dog grp78 hsa17 hsa17q hsa9q hsa9q34 hspa5 lies linkage loci map mmu2 nf1 occupy painting places probable syntenic telomeric thirds	autosomal copy ct47 d4z4 dystrophy euchromatic extreme facioscapulohumeral governed h3k27me3 h3k9me3 heterochromatic heterochromatinization hypermethylation leaky lymphoblastoid macrosatellite msrs muscular organized originating prr20 repressive testis trimethylated trimethylation understudied xq24 zav
Tagcloud (Intersection) ?