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RXRA and NR1H3
Number of citations of the paper that reports this interaction (PubMedID
15722453
)
45
Data Source:
BioGRID
(pull down)
HPRD
(two hybrid, in vivo)
RXRA
NR1H3
Description
retinoid X receptor alpha
nuclear receptor subfamily 1 group H member 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
Retinoic Acid Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Enzyme Binding
Peptide Binding
Identical Protein Binding
Nuclear Vitamin D Receptor Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
Metal Ion Binding
DNA Binding Domain Binding
LBD Domain Binding
Vitamin D Response Element Binding
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Cholesterol Binding
Chromatin DNA Binding
Sterol Response Element Binding
Sequence-specific DNA Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Nervous System Development
Hormone-mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Cell Differentiation
Monocyte Differentiation
Positive Regulation Of Bone Mineralization
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Lipid Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Cell Maturation
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Low-density Lipoprotein Particle Stimulus
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Positive Regulation Of Lipoprotein Transport
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Lipid Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Regulation Of Lipid Storage
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Intracellular Receptor Signaling Pathway
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Response To Progesterone
Positive Regulation Of Toll-like Receptor 4 Signaling Pathway
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
Regulation Of Circadian Rhythm
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Macrophage Activation
Apoptotic Cell Clearance
Positive Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Pinocytosis
Negative Regulation Of Inflammatory Response
Lipid Homeostasis
Sterol Homeostasis
Negative Regulation Of Type II Interferon-mediated Signaling Pathway
Triglyceride Homeostasis
Cellular Response To Lipopolysaccharide
Negative Regulation Of Pancreatic Juice Secretion
Negative Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
PPARA activates gene expression
Carnitine shuttle
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Cytoprotection by HMOX1
Heme signaling
TGFBR3 expression
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
PPARA activates gene expression
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs
alpha-Linolenic acid
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Etodolac
Tretinoin
Etretinate
Bezafibrate
Alfacalcidol
Phthalic Acid
Doconexent
Oleic Acid
Arachidonic Acid
EVT-101
3,20-Pregnanedione
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Tributyltin
TO-901317
N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
(2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diacerein
Rhein
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Blood pressure (
24954895
)
Central corneal thickness (
22814818
23493294
28171582
29760442
30894546
31798171
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
HDL cholesterol levels in HIV infection (
33109212
)
Intelligence (
22449649
)
Intraocular pressure (
29617998
)
Keratoconus (
33649486
)
Refractive error (
32231278
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood glucose levels (
31928498
)
Creatinine levels (
29403010
)
Feeling miserable (
29500382
)
Glycated hemoglobin levels (
34059833
)
HDL cholesterol (
20686565
19060910
)
Hypertension (
31879980
)
Intraocular pressure (
29785010
)
Lymphocyte percentage of white cells (
27863252
)
Metabolic syndrome (
22399527
)
Monocyte percentage of white cells (
27863252
)
Mood instability (
31168069
)
Neurociticism (
29500382
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Systolic blood pressure (
31928498
)
Triglyceride levels (
32154731
)
Triglycerides (
30275531
)
Interacting Genes
119 interacting genes:
ACVR1
ACVR1B
ALOX15B
ARID5A
BCL3
BMAL1
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNMT3L
DNTTIP2
EDF1
ESR1
ESRRA
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
KLF5
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A1
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCB1
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBE2I
UBQLN4
UBR5
VDR
ZBTB16
ZNHIT3
35 interacting genes:
ACTN1
APP
BAG3
CEP350
EDF1
FOXO3
GPANK1
ING3
KAT2B
KDM1A
LZTR1
MDFI
MSTO1
NCOA1
NCOA3
NCOA6
NCOR1
NR0B2
NR3C1
NRIP1
PPARA
PPARD
PPARG
PSMC5
RARA
RXRA
RXRB
RXRG
SIRT1
SS18L1
SUV39H1
SYT1
TMEM161A
UBE2I
ZXDC
Entrez ID
6256
10062
HPRD ID
01577
07211
Ensembl ID
ENSG00000186350
ENSG00000025434
Uniprot IDs
A0A5F9ZHH6
F1D8Q5
P19793
Q6P3U7
B4DXU5
B5MBY7
F1D8N1
Q13133
PDB IDs
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4CN2
4CN3
4CN5
4CN7
4J5W
4J5X
4K4J
4K6I
4M8E
4M8H
4N5G
4N8R
4NQA
4OC7
4POH
4POJ
4PP3
4PP5
4RFW
4RMC
4RMD
4RME
4ZO1
4ZSH
5EC9
5JI0
5LYQ
5MJ5
5MK4
5MKJ
5MKU
5MMW
5TBP
5UAN
5Z12
5ZQU
6A5Y
6A5Z
6A60
6FBQ
6FBR
6HN6
6JNO
6JNR
6L6K
6LB4
6LB5
6LB6
6SJM
6STI
6XWG
6XWH
7A77
7B88
7B9O
7BK4
7CFO
7NKE
7UW2
7UW4
8HBM
8PP0
1UHL
3IPQ
3IPS
3IPU
5AVI
5AVL
5HJS
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Chromatin
Nuclear Receptor Activity
Nuclear Retinoid X Receptor Binding
Nuclear Receptor-mediated Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Sequence-specific DNA Binding
Nuclear Receptor Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-templated Transcription
Transcription Coactivator Activity
Transcription By RNA Polymerase II
Nuclear Thyroid Hormone Receptor Binding
Transcription Regulator Complex
Nuclear Retinoic Acid Receptor Binding
Intracellular Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nuclear Receptor-mediated Signaling Pathway
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Nuclear Receptor Activity
Hormone-mediated Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of MiRNA Transcription
Positive Regulation Of Biosynthetic Process
Chromatin
Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Transcription Coactivator Activity
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of MiRNA Metabolic Process
Negative Regulation Of MiRNA Transcription
Intracellular Receptor Signaling Pathway
Negative Regulation Of RNA Metabolic Process
Regulation Of Primary Metabolic Process
Rhythmic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Gene Expression
Steroid Hormone Receptor Signaling Pathway
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Nuclear Retinoid X Receptor Binding
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Regulation Of Macromolecule Biosynthetic Process
Nuclear Receptor Binding
Retinoic Acid-responsive Element Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Nuclear Steroid Receptor Activity
Regulation Of Programmed Cell Death
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Oxygen-containing Compound
Regulation Of Lipid Metabolic Process
Nucleus
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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