NSD1 and NR6A1

Number of citations of the paper that reports this interaction (PMID 23975195)
1

Data Source:
BioGRID (two hybrid)

		NSD1	NR6A1
Gene Name		nuclear receptor binding SET domain protein 1	nuclear receptor subfamily 6, group A, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nucleoplasm Transcription Factor Complex
	Molecular Function	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gamete Generation Spermatogenesis Cell Proliferation Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)
Protein-Protein Interactions		27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	5 interactors: GNB5 NCOA1 NCOR1 NSD1 UIMC1
Entrez ID		64324	2649
HPRD ID		09455	04147
Ensembl ID		ENSG00000165671	ENSG00000148200
Uniprot IDs		Q96L73 Q96MN8	F1D8S0 F1DAM1 Q15406
PDB IDs		3OOI
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development	Chromatin Modification Chromatin Organization Chromosome Organization Histone Modification Diencephalon Development Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Histone H2A K63-linked Deubiquitination Regulation Of Cellular Response To Drug CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Response To Drug Definitive Erythrocyte Differentiation Regulatory T Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Female Receptivity Organelle Organization RNA Metabolic Process Male Mating Behavior Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Biosynthetic Process Carbon Catabolite Regulation Of Transcription Positive Regulation Of Metabolic Process Gene Expression Histone H3-K36 Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Thalamus Development Regulation Of Female Receptivity Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Forebrain Development Response To Radiation Female Mating Behavior Protein K63-linked Deubiquitination Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Histone H4-K20 Methylation Histone Deubiquitination Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cation Channel Activity Positive Regulation Of Histone Deacetylation Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Transcription, DNA-templated
Tagcloud ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	anteroposterior antimorph antisense cyp26 degrading derepressed embryos enhances gcnf germ hindbrain laevis morpholino nervous neuroectoderm neurogenesis oligonucleotide orphan patterning posterior presumptive ra relevance repressor spatiotemporal specification transiently xemgcnf xenopus
Tagcloud (Difference) ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	anteroposterior antimorph antisense cyp26 degrading derepressed embryos enhances gcnf germ hindbrain laevis morpholino nervous neuroectoderm neurogenesis oligonucleotide orphan patterning posterior presumptive ra relevance repressor spatiotemporal specification transiently xemgcnf xenopus
Tagcloud (Intersection) ?