NSD1 and CCDC125

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NSD1	CCDC125
Description		nuclear receptor binding SET domain protein 1	coiled-coil domain containing 125
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome	Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Nuclear Retinoic Acid Receptor Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Nuclear Thyroid Hormone Receptor Binding Histone H3K36 Methyltransferase Activity Nuclear Androgen Receptor Binding Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of DNA-templated Transcription Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Rho Protein Signal Transduction Activation Of GTPase Activity Regulation Of Cell Motility Negative Regulation Of Cell Motility
Pathways		PKMTs methylate histone lysines
Drugs
Diseases		Sotos syndrome and Weaver syndrome Beckwith-Wiedemann syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lymphocyte count ( 32888494) Narrowest width of the femoral neck ( 30888730) Neutrophil count ( 32888494) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		37 interacting genes: AGR2 AR ATRX CCDC125 CYSRT1 ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4C1 H4C16 HNF4G KRTAP6-2 MDFI NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 USP7 VDR ZNF496	64 interacting genes: AIRIM ATOSB BMP7 C21orf58 C22orf15 CCNG1 CDC23 CDK18 CEP95 DRC4 EIF3D FAM107A FAM161A FAM161B FAM47B FLYWCH1 GEM HAPLN2 HDAC4 KAT5 KIF9 KRTAP13-2 LCE2C MYH1 NEBL NSD1 NSMF OTOS PKP2 PRPF3 PTPA RAB2A RIPOR3 SFN SNW1 SPMIP2 STX11 TCHP TEAD4 TRIM14 TSGA10IP UACA YWHAE YWHAH YWHAQ YWHAZ ZFP1 ZFYVE26 ZNF165 ZNF230 ZNF250 ZNF32 ZNF337 ZNF343 ZNF417 ZNF436 ZNF552 ZNF557 ZNF564 ZNF587 ZNF764 ZNF792 ZNF837 ZNF883
Entrez ID		64324	202243
HPRD ID		09455	13774
Ensembl ID		ENSG00000165671	ENSG00000183323
Uniprot IDs		A0A8I5QJP2 Q96L73 Q96MN8	B4DSR1 Q2HJ12 Q86Z20
PDB IDs		3OOI 6KQP 6KQQ 8C5L
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Gene Expression Nuclear Steroid Receptor Activity Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Retinoic Acid Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process MRNA Transcription Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Metabolic Process Nucleosome Assembly Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Biosynthetic Process Nucleosome Organization Regulation Of Metabolic Process Structural Constituent Of Chromatin Transcription By RNA Polymerase II Chromatin DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Estrogen Response Element Binding Positive Regulation Of RNA Metabolic Process	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Phosphoserine Residue Binding Zinc Ion Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Binding Transmembrane Transporter Binding
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