Gene Name |
retinoid X receptor, alpha |
estrogen receptor 1 |
Image |
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Gene Ontology Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
- Bile acid and bile salt metabolism
- Metabolism of lipids and lipoproteins
- Nuclear Receptor transcription pathway
- Metabolic disorders of biological oxidation enzymes
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Generic Transcription Pathway
- Endogenous sterols
- Synthesis of bile acids and bile salts
- Orphan transporters
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Signaling by Retinoic Acid
- Recycling of bile acids and salts
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Regulation of pyruvate dehydrogenase (PDH) complex
- Pyruvate metabolism
- Synthesis of bile acids and bile salts via 27-hydroxycholesterol
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Activation of gene expression by SREBF (SREBP)
- The citric acid (TCA) cycle and respiratory electron transport
- Transcriptional activation of mitochondrial biogenesis
- PPARA activates gene expression
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Organelle biogenesis and maintenance
- Import of palmitoyl-CoA into the mitochondrial matrix
- Pyruvate metabolism and Citric Acid (TCA) cycle
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Phase 1 - Functionalization of compounds
- RORA activates circadian gene expression
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Cytochrome P450 - arranged by substrate type
- Transcriptional regulation of white adipocyte differentiation
- Biological oxidations
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Fatty acid, triacylglycerol, and ketone body metabolism
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- REV-ERBA represses gene expression
- Defective CYP1B1 causes Glaucoma
- Mitochondrial biogenesis
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
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Drugs |
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- Diethylstilbestrol
- Chlorotrianisene
- Conjugated Estrogens
- Etonogestrel
- Desogestrel
- Levonorgestrel
- Progesterone
- Raloxifene
- Toremifene
- Medroxyprogesterone
- Estrone
- Tamoxifen
- Estradiol
- Ethynodiol Diacetate
- Clomifene
- Dienestrol
- Fulvestrant
- Norgestimate
- Ethinyl Estradiol
- Melatonin
- Trilostane
- Naloxone
- Fluoxymesterone
- Estramustine
- Mestranol
- Danazol
- Allylestrenol
- Genistein
- Compound 19
- Compound 18
- Compound 4-D
- 1-[4-(Octahydro-Pyrido[1,2-a]Pyrazin-2-Yl)-Phenyl]-2-Phenyl-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol
- 2-Phenyl-1-[4-(2-Piperidin-1-Yl-Ethoxy)-Phenyl]-1,2,3,4-Tetrahydro-Isoquinolin-6-Ol
- Estriol
- Estropipate
- Quinestrol
- Ospemifene
- 17-METHYL-17-ALPHA-DIHYDROEQUILENIN
- 4-(2-amino-1-methyl-1H-imidazo[4,5-b]pyridin-6-yl)phenol
- [5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE
- 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- 4-[(1S,2S,5S,9R)-5-(HYDROXYMETHYL)-8,9-DIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-6,8,9-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- (2R,3R,4S)-3-(4-HYDROXYPHENYL)-4-METHYL-2-[4-(2-PYRROLIDIN-1-YLETHOXY)PHENYL]CHROMAN-6-OL
- (3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- (9ALPHA,13BETA,17BETA)-2-[(1Z)-BUT-1-EN-1-YL]ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
- (9BETA,11ALPHA,13ALPHA,14BETA,17ALPHA)-11-(METHOXYMETHYL)ESTRA-1(10),2,4-TRIENE-3,17-DIOL
- 3-CHLORO-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
- 3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL
- dimethyl (1R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- N-[(1R)-3-(4-HYDROXYPHENYL)-1-METHYLPROPYL]-2-(2-PHENYL-1H-INDOL-3-YL)ACETAMIDE
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL
- 4-[1-allyl-7-(trifluoromethyl)-1H-indazol-3-yl]benzene-1,3-diol
- 4-(6-HYDROXY-1H-INDAZOL-3-YL)BENZENE-1,3-DIOL
- DIETHYL (1R,2S,3R,4S)-5,6-BIS(4-HYDROXYPHENYL)-7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLATE
- 2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE
- 4-[(1S,2R,5S)-4,4,8-TRIMETHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL
- (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-9-OL
- RALOXIFENE CORE
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Diseases |
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GWAS |
- Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065)
- Central corneal thickness ( 22814818 23493294)
- Corneal structure ( 23291589)
- Crohn's disease (need for surgery) ( 23665963)
- Intelligence ( 22449649)
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Protein-Protein Interactions |
113 interactors:
ACVR1
ACVR1B
ALOX15B
ARID5A
ARNTL
BCL3
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNTTIP2
EDF1
ESR1
ESR2
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBQLN4
VDR
ZBTB16
ZNHIT3
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266 interactors:
ACTN4
AHR
AKAP13
AKT1
AKT2
AR
ARHGEF15
ARNT
ATAD2
BAG1
BCAR1
BCAS2
BDNF
BRCA1
BTF3
CALM1
CALM2
CALM3
CAV1
CBLL1
CCNC
CCND1
CCNH
CCNT1
CDC25B
CDK2
CDK7
CDK8
CDKN1A
CEBPA
CEBPB
CHD9
CHUK
CITED1
COPS5
CREBBP
CSNK2B
CTNNB1
CUEDC2
CUL4B
DAP3
DDX5
DDX54
DNTTIP2
DUT
EGFR
EHMT2
EIF3I
EP300
ERBB2
ESR2
ESRRA
FHL2
FKBP4
FKBP5
FLII
FOXO1
FOXO3
FOXO4
GADD45B
GADD45G
GNAI1
GNAI2
GNAI3
GRB2
GRIP1
GTF2B
GTF2H1
HDAC4
HDAC5
HDAC9
HEXIM1
HNF4A
HSP90AA1
HSP90AB1
HSPA4
HSPA8
IGF1R
ING1
ISL1
ITGB3BP
JUN
JUNB
JUND
KAT5
KDM5A
KIF1A
KLF5
KMT2D
LCK
LCOR
LDB1
LINC00312
LRIF1
MAPK1
MAPK14
MAPK3
MDM2
MED1
MED10
MED12
MED13
MED14
MED16
MED17
MED20
MED21
MED23
MED24
MED25
MED6
MED7
MEN1
MGMT
MKNK2
MMS19
MNAT1
MPG
MSH2
MTA1
MTA2
MTA3
MTCH2
MUC1
MVP
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOA7
NCOR1
NCOR2
NELFB
NFKB1
NPPA
NR0B1
NR0B2
NR1H4
NR2C1
NR2C2
NR2F1
NR2F6
NRIP1
NSD1
OTUB1
PAGR1
PAK1
PAK6
PELP1
PGC
PGR
PHB
PHB2
PIAS1
PIAS2
PIAS3
PIK3R1
PIK3R3
PNRC2
POLR1B
POLR2D
POU2F1
POU2F2
POU4F1
POU4F2
PPARG
PPARGC1A
PPARGC1B
PPID
PRDM2
PRKACA
PRMT1
PRMT2
PRPF6
PSMC5
PTEN
PTGES3
PTMA
PTPN1
PTPN6
RAC3
RANBP9
RARA
RBBP4
RBBP7
RBFOX2
RBM23
RBM39
RELA
REXO4
RFX4
RGS3
RLIM
RNF14
RNF4
RPS6KA1
RPS6KA3
RXRA
SAFB
SAFB2
SETD7
SF1
SHC1
SKIL
SKP2
SLC30A9
SMAD2
SMAD3
SMAD4
SMARCA2
SMARCA4
SMARCD1
SMARCD3
SMARCE1
SMURF1
SMYD2
SOS1
SP1
SP3
SRA1
SRC
SREBF1
STAT5A
STRN
STUB1
SUMO1
SUV39H1
SUV420H1
SVIL
TAB2
TADA3
TAF10
TAF1A
TAF1B
TAF2
TAP1
TBP
TCF20
TDG
THRA
THRB
TNFRSF14
TP53
TRAM1
TRIM24
TRIM25
TRIM28
TRIM59
TRIP4
TRRAP
TSC2
TUBA1B
TUBB
UBE2I
UIMC1
USF1
VAV3
WHSC1
WIPI1
XBP1
YWHAH
YWHAQ
ZBTB16
ZBTB17
ZNF398
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Entrez ID |
6256 |
2099 |
HPRD ID |
01577 |
00589 |
Ensembl ID |
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ENSG00000091831
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Uniprot IDs |
F1D8Q5
P19793
Q6P3U7
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G4XH65
P03372
Q9UBT1
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PDB IDs |
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1LBD
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4J5W
4J5X
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1A52
1AKF
1ERE
1ERR
1G50
1GWQ
1GWR
1HCP
1HCQ
1L2I
1PCG
1QKT
1QKU
1R5K
1SJ0
1UOM
1X7E
1X7R
1XP1
1XP6
1XP9
1XPC
1XQC
1YIM
1YIN
1ZKY
2AYR
2B1V
2B1Z
2B23
2BJ4
2FAI
2G44
2G5O
2I0J
2IOG
2IOK
2JF9
2JFA
2LLO
2LLQ
2OCF
2OUZ
2P15
2POG
2Q6J
2Q70
2QA6
2QA8
2QAB
2QE4
2QGT
2QGW
2QH6
2QR9
2QSE
2QXM
2QXS
2QZO
2R6W
2R6Y
2YAT
2YJA
3CBM
3CBO
3CBP
3DT3
3ERD
3ERT
3HLV
3HM1
3L03
3OS8
3OS9
3OSA
3Q95
3Q97
3UU7
3UUA
3UUC
3UUD
4AA6
4DMA
4IU7
4IUI
4IV2
4IV4
4IVW
4IVY
4IW6
4IW8
4IWC
4IWF
4JC3
4JDD
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
17q
22cm
canine
centromeric
cfa9
correspond
cosmid
cryba1
distal
dog
grp78
hsa17
hsa17q
hsa9q
hsa9q34
hspa5
lies
linkage
loci
map
mmu2
nf1
occupy
painting
places
probable
syntenic
telomeric
thirds
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analyzing
brca1
carcinogenic
changed
characters
coactivator
concordant
conduct
differentiationassociated
discovered
downloaded
e2
enrichment
estradiol
go
gses9623
gsm986085
gsm986087
guidance
macs
mcf7
omnibus
ontology
p300bound
p300regulated
participated
peakcalling
software
theoretical
|
Tagcloud (Difference) ? |
17q
22cm
canine
centromeric
cfa9
correspond
cosmid
cryba1
distal
dog
grp78
hsa17
hsa17q
hsa9q
hsa9q34
hspa5
lies
linkage
loci
map
mmu2
nf1
occupy
painting
places
probable
syntenic
telomeric
thirds
|
analyzing
brca1
carcinogenic
changed
characters
coactivator
concordant
conduct
differentiationassociated
discovered
downloaded
e2
enrichment
estradiol
go
gses9623
gsm986085
gsm986087
guidance
macs
mcf7
omnibus
ontology
p300bound
p300regulated
participated
peakcalling
software
theoretical
|
Tagcloud (Intersection) ? |
|