Wiki-Pi
About
Search
People
Updates
Search
RXRA and NFKB1
Number of citations of the paper that reports this interaction (PubMedID
10075655
)
0
Data Source:
HPRD
(in vitro)
RXRA
NFKB1
Description
retinoid X receptor alpha
nuclear factor kappa B subunit 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Receptor Complex
RNA Polymerase II Transcription Regulator Complex
Chromatin
Extracellular Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
I-kappaB/NF-kappaB Complex
Secretory Granule Lumen
NF-kappaB P50/p65 Complex
Specific Granule Lumen
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
Retinoic Acid Binding
DNA Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Steroid Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Enzyme Binding
Peptide Binding
Identical Protein Binding
Nuclear Vitamin D Receptor Binding
Sequence-specific DNA Binding
Retinoic Acid-responsive Element Binding
Metal Ion Binding
DNA Binding Domain Binding
LBD Domain Binding
Vitamin D Response Element Binding
Sequence-specific Double-stranded DNA Binding
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Transcription Coregulator Activity
Protein Binding
Identical Protein Binding
Actinin Binding
Sequence-specific DNA Binding
Protein Sequestering Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Nervous System Development
Hormone-mediated Signaling Pathway
Positive Regulation Of Cholesterol Efflux
Cell Differentiation
Monocyte Differentiation
Positive Regulation Of Bone Mineralization
Nuclear Receptor-mediated Steroid Hormone Signaling Pathway
Response To Retinoic Acid
Peroxisome Proliferator Activated Receptor Signaling Pathway
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Lipid Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Cell Maturation
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Low-density Lipoprotein Particle Stimulus
Nuclear Protein Quality Control By The Ubiquitin-proteasome System
Positive Regulation Of Lipoprotein Transport
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Cytokine Production
Immune System Process
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Apoptotic Process
Inflammatory Response
Signal Transduction
Canonical NF-kappaB Signal Transduction
JNK Cascade
Gene Expression
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Vitamin D Biosynthetic Process
Signal Transduction Involved In Regulation Of Gene Expression
Negative Regulation Of Interleukin-12 Production
Tumor Necrosis Factor-mediated Signaling Pathway
Response To Muscle Stretch
Non-canonical NF-kappaB Signal Transduction
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
B Cell Receptor Signaling Pathway
Mammary Gland Involution
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nicotine
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To DsRNA
Positive Regulation Of Canonical Wnt Signaling Pathway
Cellular Response To Interleukin-17
Cellular Response To Virus
Antibacterial Innate Immune Response
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Hyaluronan Biosynthetic Process
Cellular Response To Angiotensin
Positive Regulation Of MiRNA Metabolic Process
Pathways
BMAL1:CLOCK,NPAS2 activates circadian expression
Recycling of bile acids and salts
Synthesis of bile acids and bile salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
PPARA activates gene expression
PPARA activates gene expression
Carnitine shuttle
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Cytoprotection by HMOX1
Heme signaling
TGFBR3 expression
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Expression of BMAL (ARNTL), CLOCK, and NPAS2
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
Regulated proteolysis of p75NTR
Downstream TCR signaling
NF-kB is activated and signals survival
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated NF-kB activation
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
PKMTs methylate histone lysines
Transcriptional regulation of white adipocyte differentiation
TAK1-dependent IKK and NF-kappa-B activation
Interleukin-1 processing
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
CD209 (DC-SIGN) signaling
CLEC7A/inflammasome pathway
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neutrophil degranulation
The NLRP3 inflammasome
Transcriptional Regulation by VENTX
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
HCMV Early Events
Purinergic signaling in leishmaniasis infection
SARS-CoV-1 activates/modulates innate immune responses
Regulation of NFE2L2 gene expression
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Regulation of PD-L1(CD274) transcription
Drugs
alpha-Linolenic acid
Adapalene
Bexarotene
Rosiglitazone
Acitretin
Alitretinoin
Etodolac
Tretinoin
Etretinate
Bezafibrate
Alfacalcidol
Phthalic Acid
Doconexent
Oleic Acid
Arachidonic Acid
EVT-101
3,20-Pregnanedione
2-chloro-5-nitro-N-phenylbenzamide
1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE
2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID
Tributyltin
Sulfasalazine
Donepezil
Pseudoephedrine
Pranlukast
Pranlukast
HE3286
P54
NOX-700
SGN-30
Custirsen
NF-kappaB Decoy
Andrographolide
Triflusal
Terpinen-4-ol
Glycyrrhizic acid
Fish oil
SC-236
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) (
23648065
)
Blood pressure (
24954895
)
Central corneal thickness (
22814818
23493294
28171582
29760442
30894546
31798171
)
Corneal structure (
23291589
)
Crohn's disease (need for surgery) (
23665963
)
HDL cholesterol levels in HIV infection (
33109212
)
Intelligence (
22449649
)
Intraocular pressure (
29617998
)
Keratoconus (
33649486
)
Refractive error (
32231278
)
Waist-to-hip ratio adjusted for BMI x sex interaction (
26426971
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
30013184
)
Basophil percentage of white cells (
32888494
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Copper levels (
26025379
)
Creatinine levels (
29124443
)
Crohn's disease (
28067908
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Estimated glomerular filtration rate (
29124443
30604766
)
Glomerular filtration rate (creatinine) (
26831199
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Homeostasis model assessment of beta-cell function (dietary factor interaction) (
24204828
)
Immature fraction of reticulocytes (
32888494
)
Inflammatory bowel disease (
28067908
)
Lymphocyte count (
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Membranous nephropathy (
32231244
)
Monocyte percentage of white cells (
27863252
)
Multiple sclerosis (
21833088
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
27863252
)
Non-albumin protein levels (
29403010
)
Primary biliary cholangitis (
28425483
23000144
26394269
28062665
21399635
30643196
)
Primary biliary cirrhosis (
22961000
)
Primary sclerosing cholangitis (
27992413
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Schizophrenia (treatment resistant) (
22479419
)
Serum total protein levels (
29403010
)
Serum uric acid levels (
29124443
)
Sum eosinophil basophil counts (
27863252
)
Systemic sclerosis (
31672989
30247649
)
Tonsillectomy (
27182965
28928442
)
Ulcerative colitis (
23128233
)
White blood cell count (
32888494
)
Interacting Genes
119 interacting genes:
ACVR1
ACVR1B
ALOX15B
ARID5A
BCL3
BMAL1
BRD8
CASP2
CHD9
CLOCK
CNOT1
COPS2
CSNK2B
CTCF
CTNNB1
CTSL
DNMT3L
DNTTIP2
EDF1
ESR1
ESRRA
FUS
GADD45A
GADD45G
GATA2
GK
GRIP1
GSK3B
HDAC3
HDAC4
HMGA1
IGFBP3
ITGB3BP
JAZF1
JMJD1C
KIF1A
KLF5
MAPK1
MAPK3
MAPK7
MECR
MED1
MED24
MED25
MPG
MYOD1
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NFKB1
NFKBIB
NPAS2
NR0B2
NR1H2
NR1H3
NR1H4
NR1I2
NR1I3
NR2E3
NR2F1
NR2F6
NR3C2
NR4A1
NR4A2
NRBF2
NRIP1
NSD1
PARP1
PLK1
PML
POU2F1
POU2F2
PPARA
PPARD
PPARG
PPARGC1A
PRKD2
PRMT2
PSMC3IP
PSMC5
RAD54L2
RARA
RARB
RARG
RELA
RNF8
ROBO4
RPS6KA6
SMAD2
SMARCB1
SMARCD3
SMN1
SNW1
SP1
SRC
SRF
STAT1
TADA3
TAF11
TAF1B
TBP
TDG
THRA
THRB
TK1
TMPRSS3
TRIM24
TRIP10
TRIP4
UBE2I
UBQLN4
UBR5
VDR
ZBTB16
ZNHIT3
106 interacting genes:
ABCC2
APBB2
AR
ATF3
BARD1
BCL3
BRCA1
BTRC
CDK9
CEBPB
CFLAR
CHUK
COPB2
COPS5
CTNNB1
DNMT3L
E2F1
ECSIT
ELF1
ELF3
ESR1
ETS1
FBXO7
FBXW11
FOS
G3BP2
GLUL
GSK3B
HDAC1
HMGA1
HMGA2
HMGB1
HSPA4
IKBKB
IKBKG
IL2RA
IRF1
IRF2
IRF8
IRF9
ITGB3BP
KAT5
KLF5
KPNA3
LYL1
MAP3K8
MEN1
MTPN
NCOA1
NCOA6
NCOR2
NFKB2
NFKBIA
NFKBIB
NFKBIE
NFKBIZ
NFRKB
NKRF
NOTCH1
NR3C1
NR4A1
PALS2
PARP1
PCBD1
PDCD11
PELP1
PLD3
PML
PPARG
PPP4C
PRKACA
PSMD10
REL
RELA
RELB
RGS14
RIPK1
RPS3
RSF1
RXRA
SERPINA3
SF1
SIN3A
SP1
SPAG9
SPI1
SPPL2A
SRF
STAT3
STAT6
TAB2
TFAP2A
TNFSF11
TNIP2
TP53BP1
TP53BP2
TRIP4
TSC22D3
TXN
UBE2D2
UBE2D3
UBE2K
UNC5CL
YWHAQ
YY1
ZBTB9
Entrez ID
6256
4790
HPRD ID
01577
01238
Ensembl ID
ENSG00000186350
ENSG00000109320
Uniprot IDs
A0A5F9ZHH6
F1D8Q5
P19793
Q6P3U7
P19838
PDB IDs
1BY4
1DSZ
1FBY
1FM6
1FM9
1G1U
1G5Y
1K74
1MV9
1MVC
1MZN
1R0N
1RDT
1RXR
1XLS
1XV9
1XVP
1YNW
2ACL
2NLL
2P1T
2P1U
2P1V
2ZXZ
2ZY0
3DZU
3DZY
3E00
3E94
3FAL
3FC6
3FUG
3H0A
3KWY
3NSP
3NSQ
3OAP
3OZJ
3PCU
3R29
3R2A
3R5M
3UVV
4CN2
4CN3
4CN5
4CN7
4J5W
4J5X
4K4J
4K6I
4M8E
4M8H
4N5G
4N8R
4NQA
4OC7
4POH
4POJ
4PP3
4PP5
4RFW
4RMC
4RMD
4RME
4ZO1
4ZSH
5EC9
5JI0
5LYQ
5MJ5
5MK4
5MKJ
5MKU
5MMW
5TBP
5UAN
5Z12
5ZQU
6A5Y
6A5Z
6A60
6FBQ
6FBR
6HN6
6JNO
6JNR
6L6K
6LB4
6LB5
6LB6
6SJM
6STI
6XWG
6XWH
7A77
7B88
7B9O
7BK4
7CFO
7NKE
7UW2
7UW4
8HBM
8PP0
1MDI
1MDJ
1MDK
1NFI
1SVC
2DBF
2O61
3GUT
7LEQ
7LET
7LF4
7LFC
7RG4
7RG5
8TQD
Enriched GO Terms of Interacting Partners
?
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Nucleoplasm
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Nucleus
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Gene Expression
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Chromatin
Nuclear Receptor Activity
Nuclear Retinoid X Receptor Binding
Nuclear Receptor-mediated Signaling Pathway
Regulation Of Macromolecule Metabolic Process
Hormone-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Sequence-specific DNA Binding
Nuclear Receptor Binding
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Metabolic Process
DNA-binding Transcription Factor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-templated Transcription
Transcription Coactivator Activity
Transcription By RNA Polymerase II
Nuclear Thyroid Hormone Receptor Binding
Transcription Regulator Complex
Nuclear Retinoic Acid Receptor Binding
Intracellular Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Cellular Response To Hormone Stimulus
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Gene Expression
Nucleoplasm
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Nucleus
Chromatin
Transcription Cis-regulatory Region Binding
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Response To Stress
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Regulation Of Apoptotic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Programmed Cell Death
Negative Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Intracellular Signal Transduction
Response To Cytokine
Response To Peptide
Sequence-specific DNA Binding
Regulation Of Intracellular Signal Transduction
Canonical NF-kappaB Signal Transduction
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Non-canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Developmental Process
Transcription Regulator Complex
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?