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NSD1 and HIST1H1B
Number of citations of the paper that reports this interaction (PMID
24412544
)
0
Data Source:
BioGRID
(enzymatic study)
NSD1
HIST1H1B
Gene Name
nuclear receptor binding SET domain protein 1
histone cluster 1, H1b
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Nucleosome
Nuclear Chromatin
Nuclear Heterochromatin
Extracellular Vesicular Exosome
Molecular Function
Chromatin Binding
Transcription Cofactor Activity
Transcription Corepressor Activity
Zinc Ion Binding
Estrogen Receptor Binding
Histone Methyltransferase Activity (H4-K20 Specific)
Retinoic Acid Receptor Binding
Retinoid X Receptor Binding
Thyroid Hormone Receptor Binding
Histone Methyltransferase Activity (H3-K36 Specific)
Androgen Receptor Binding
Chromatin DNA Binding
Histone Deacetylase Binding
Poly(A) RNA Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Gastrulation With Mouth Forming Second
Chromatin Organization
Transcription, DNA-templated
Histone H3-K36 Methylation
Histone Methylation
Histone H4-K20 Methylation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Organization
Nucleosome Assembly
Positive Regulation Of Cell Growth
Protein Stabilization
Positive Regulation Of Histone H3-K9 Methylation
Establishment Of Protein Localization To Chromatin
Pathways
Chromatin modifying enzymes
Chromatin organization
PKMTs methylate histone lysines
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Activation of DNA fragmentation factor
Apoptosis induced DNA fragmentation
Cellular Senescence
Programmed Cell Death
Apoptotic execution phase
Drugs
Diseases
GWAS
Activated partial thromboplastin time (
22703881
)
Protein-Protein Interactions
27 interactors:
AR
ATRX
ESR1
ESRRA
HIST1H1B
HIST1H1C
HIST1H1D
HIST3H3
HIST4H4
HNF4G
NR2E1
NR2F1
NR2F2
NR2F6
NR5A2
NR6A1
PPARG
RARA
RORA
RORB
RXRA
SNORD3A
THRA
THRB
TNFRSF21
VDR
ZNF496
26 interactors:
CBX5
CCNA1
CCNA2
CCNB1
CCNE1
CDK1
CDK2
CDK5
CDKN1A
CDKN1B
EHMT2
IRAK4
KAT2A
KAT2B
L3MBTL1
LOX
MELK
MLLT1
NSD1
PRKCA
PRKCB
PRKCD
PRKCZ
RPS6KA5
SERPINH1
SIRT1
Entrez ID
64324
3009
HPRD ID
09455
00821
Ensembl ID
ENSG00000165671
ENSG00000184357
Uniprot IDs
Q96L73
Q96MN8
P16401
PDB IDs
3OOI
2FE2
2RHI
Enriched GO Terms of Interacting Partners
?
Steroid Hormone Mediated Signaling Pathway
Hormone-mediated Signaling Pathway
Cellular Response To Steroid Hormone Stimulus
Transcription Initiation From RNA Polymerase II Promoter
Intracellular Receptor Signaling Pathway
DNA-templated Transcription, Initiation
Cellular Response To Organic Cyclic Compound
Cellular Response To Lipid
Response To Steroid Hormone
Cellular Response To Hormone Stimulus
Transcription From RNA Polymerase II Promoter
Response To Lipid
Response To Organic Cyclic Compound
Response To Hormone
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Transcription, DNA-templated
RNA Biosynthetic Process
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Gene Expression
Regulation Of Transcription, DNA-templated
RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Organ Development
System Development
Regulation Of Protein Kinase Activity
Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Histone Modification
Peptidyl-amino Acid Modification
Chromatin Modification
Regulation Of Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Cell Cycle
Regulation Of Cell Cycle
Regulation Of Phosphorus Metabolic Process
Regulation Of Protein Metabolic Process
Chromatin Organization
Histone Phosphorylation
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Nitrogen Compound Metabolic Process
Cellular Protein Modification Process
Regulation Of Mitotic Cell Cycle
Cell Cycle Process
Negative Regulation Of Protein Phosphorylation
Negative Regulation Of Cellular Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Gene Expression
Mitotic Cell Cycle
Chromosome Organization
Regulation Of Catalytic Activity
Negative Regulation Of Phosphorylation
Protein Phosphorylation
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Cellular Protein Metabolic Process
Response To Stress
Response To Organic Substance
Positive Regulation Of Cellular Metabolic Process
Negative Regulation Of Protein Metabolic Process
Protein Metabolic Process
Response To Wounding
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Cellular Protein Metabolic Process
Peptidyl-threonine Phosphorylation
Peptidyl-serine Phosphorylation
Regulation Of RNA Metabolic Process
Negative Regulation Of Protein Kinase Activity
Regulation Of Metabolic Process
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Kinase Activity
Positive Regulation Of Cell Proliferation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Wound Healing
Tagcloud
?
abrogated
af
apo
bifunctional
box
coactivators
contains
corepressors
drosophila
fingers
fxxll
helix
holo
interacts
intermediary
lbd
lbds
liganded
lxxll
nid
nids
nr
nrs
phd
playing
separate
severely
tr
unliganded
Tagcloud (Difference)
?
abrogated
af
apo
bifunctional
box
coactivators
contains
corepressors
drosophila
fingers
fxxll
helix
holo
interacts
intermediary
lbd
lbds
liganded
lxxll
nid
nids
nr
nrs
phd
playing
separate
severely
tr
unliganded
Tagcloud (Intersection)
?