NSD1 and HIST1H1D

Number of citations of the paper that reports this interaction (PMID 24412544)
0

Data Source:
BioGRID (enzymatic study)

		NSD1	HIST1H1D
Gene Name		nuclear receptor binding SET domain protein 1	histone cluster 1, H1d
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nucleosome Nuclear Chromatin Nuclear Euchromatin
	Molecular Function	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	Chromatin DNA Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated	Nucleosome Assembly Nucleosome Positioning
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Height ( 19343178 18391950)
Protein-Protein Interactions		27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	7 interactors: CDK1 CDK2 CDK4 EP300 IRAK4 NSD1 PRKCA
Entrez ID		64324	3007
HPRD ID		09455	06764
Ensembl ID		ENSG00000165671	ENSG00000124575
Uniprot IDs		Q96L73 Q96MN8	P16402
PDB IDs		3OOI
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development	Chromatin Organization Histone Modification Chromosome Organization Histone Phosphorylation Chromatin Modification Mitotic Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cell Cycle Cellular Protein Modification Process Positive Regulation Of Cell Proliferation Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cellular Protein Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Cell Cycle Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Organelle Organization Protein Metabolic Process Innate Immune Response Mitotic Nuclear Envelope Disassembly Phosphorylation Intracellular Signal Transduction Positive Regulation Of Metabolic Process Response To Stress Nuclear Envelope Disassembly Regulation Of Cellular Protein Metabolic Process Peptidyl-threonine Phosphorylation Peptidyl-amino Acid Modification Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Centrosome Cycle Regulation Of Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of DNA Replication Nuclear Envelope Organization Organ Regeneration
Tagcloud ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded
Tagcloud (Difference) ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded
Tagcloud (Intersection) ?