NSD1 and HNF4G

Number of citations of the paper that reports this interaction (PMID 23975195)
1

Data Source:
BioGRID (two hybrid)

		NSD1	HNF4G
Gene Name		nuclear receptor binding SET domain protein 1	hepatocyte nuclear factor 4, gamma
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus	Nucleoplasm
	Molecular Function	Chromatin Binding Transcription Cofactor Activity Transcription Corepressor Activity Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gastrulation With Mouth Forming Second Chromatin Organization Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gene Expression Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines	Regulation of beta-cell development Generic Transcription Pathway Regulation of gene expression in beta cells Nuclear Receptor transcription pathway
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881)	Body mass index ( 20935630) Breast cancer ( 23535729) Obesity ( 23563607) Urate levels ( 23263486)
Protein-Protein Interactions		27 interactors: AR ATRX ESR1 ESRRA HIST1H1B HIST1H1C HIST1H1D HIST3H3 HIST4H4 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 PPARG RARA RORA RORB RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496	14 interactors: COPS5 EIF3I GAPDH HAX1 HLF NCOA1 NR0B2 NSD1 PNRC1 PNRC2 PRDX6 RANBP9 SRC TNNI2
Entrez ID		64324	3174
HPRD ID		09455	06909
Ensembl ID		ENSG00000165671	ENSG00000164749
Uniprot IDs		Q96L73 Q96MN8	F1D8Q4 Q14541
PDB IDs		3OOI	1LV2
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Transcription Initiation From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Transcription From RNA Polymerase II Promoter Response To Lipid Response To Organic Cyclic Compound Response To Hormone Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Transcription, DNA-templated RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organ Development System Development	Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To Progesterone Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Peptidyl-cysteine S-trans-nitrosylation Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling RNA Metabolic Process Cellular Response To Progesterone Stimulus Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Drug Peptidyl-amino Acid Modification Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Targeting To Mitochondrion Exosomal Secretion Response To Steroid Hormone Regulation Of Protein Kinase B Signaling Peptidyl-cysteine S-nitrosylation Positive Regulation Of Integrin Activation Positive Regulation Of Podosome Assembly Regulation Of Response To Drug Negative Regulation Of Mitochondrial Depolarization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Negative Regulation Of Protein Homooligomerization Progesterone Receptor Signaling Pathway Positive Regulation Of Female Receptivity Regulation Of Podosome Assembly Cellular Response To Hormone Stimulus Male Mating Behavior Regulation Of Caveolin-mediated Endocytosis Mammary Gland Development
Tagcloud ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist zzz3
Tagcloud (Difference) ?		abrogated af apo bifunctional box coactivators contains corepressors drosophila fingers fxxll helix holo interacts intermediary lbd lbds liganded lxxll nid nids nr nrs phd playing separate severely tr unliganded	5th adcy9 ancestry broader classes etiological exploiting extremes generalizable gnat2 h6pd height hip hs6st3 igfbp4 influencing loci mrps33p4 obesity overlap percentiles ppp2r2a rptor rsrc1 tails trait traits waist zzz3
Tagcloud (Intersection) ?