SRSF3 and EXOSC6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		SRSF3	EXOSC6
Gene Name		serine/arginine-rich splicing factor 3	exosome component 6
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm	Exosome (RNase Complex) Nucleolus Cytosol
	Molecular Function	Nucleotide Binding RNA Binding Protein Binding Poly(A) RNA Binding	Exoribonuclease Activity Poly(A) RNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome Transcription From RNA Polymerase II Promoter Termination Of RNA Polymerase II Transcription MRNA Export From Nucleus RNA Splicing Gene Expression MRNA 3'-end Processing	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching
Pathways		mRNA Splicing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway Transport of Mature Transcript to Cytoplasm Cleavage of Growing Transcript in the Termination Region RNA Polymerase II Transcription Termination mRNA 3'-end processing	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP CHD1 CLK1 EXOSC6 GEMIN2 HNRNPK IL7R NXF1 PCBP1 PCBP2 PRPF38A RBM7 RBMY1A1 SCAF11 SREK1 SRPK1 SRPK2 SRSF2 TRA2B YWHAB YWHAG YWHAQ	35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		6428	118460
HPRD ID		04530	12107
Ensembl ID			ENSG00000223496
Uniprot IDs		B2R6F3 P84103	Q5RKV6
PDB IDs		2I2Y 2I38	2NN6
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing RNA Splicing RNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of MRNA Processing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrion Organization Spliceosomal Complex Assembly Regulation Of Mitochondrion Organization Immune Response Positive Regulation Of Viral Genome Replication Ribonucleoprotein Complex Biogenesis Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Nitrogen Compound Metabolic Process Ribonucleoprotein Complex Assembly Intrinsic Apoptotic Signaling Pathway Innate Immune Response Positive Regulation Of Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Viral Genome Replication Cellular Metabolic Process Nuclear Speck Organization Positive Regulation Of Intracellular Transport Immunoglobulin Production Cellular Process MRNA Export From Nucleus Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Intracellular Transport Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Interleukin-7-mediated Signaling Pathway RNA Export From Nucleus Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Cell Death	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud ?		1alpha activate alter atpase cadherin caffeine cardiac conferred depletion detailed digoxin g2 glycosides governing hela hypoxia isoform mesenchymal modulate modulated na p53alpha p53beta pumping repositioning snail splicing switch transition
Tagcloud (Difference) ?		1alpha activate alter atpase cadherin caffeine cardiac conferred depletion detailed digoxin g2 glycosides governing hela hypoxia isoform mesenchymal modulate modulated na p53alpha p53beta pumping repositioning snail splicing switch transition
Tagcloud (Intersection) ?