SRSF3 and RNPS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SRSF3	RNPS1
Description		serine and arginine rich splicing factor 3	RNA binding protein with serine rich domain 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome DNA-templated Transcription MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ	55 interacting genes: ABI2 CCNL1 CHERP CLK2 CLK3 DVL2 ELOA2 FAM81B GOLGA6L9 GPATCH8 HEXIM2 HOXD4 LUC7L3 NKTR OGT PICK1 PIN1 PNN PRPF38A PSTPIP1 RBMY1F RBMY1J SAP18 SART3 SDCBP2 SRP54 SRRM4 SRSF1 SRSF11 SRSF3 SRSF6 SRSF7 SRSF9 STX11 TBC1D26 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 USP4 YTHDC1 YWHAB YWHAG ZBTB14 ZNF165 ZNF286A ZNF345 ZNF394 ZNF41 ZNF473 ZNF490 ZNF660 ZSCAN30
Entrez ID		6428	10921
HPRD ID		04530	07341
Ensembl ID		ENSG00000112081	ENSG00000205937
Uniprot IDs		B2R6F3 P84103	D3DU92 H3BMS0 Q15287
PDB IDs		2I2Y 2I38 9ASQ	4A8X
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex	MRNA Processing RNA Splicing Regulation Of RNA Splicing Nuclear Speck MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleus Regulation Of MRNA Processing RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Binding Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process MRNA Splice Site Recognition Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Exon-exon Junction Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Identical Protein Binding Protein Domain Specific Binding Negative Regulation Of MRNA Metabolic Process Pre-mRNA Binding MRNA Transport ASAP Complex RNA Transport Phosphoserine Residue Binding RS Domain Binding Protein Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nucleobase-containing Compound Transport Cajal Body
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