SRSF3 and PCDHB14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SRSF3	PCDHB14
Description		serine and arginine rich splicing factor 3	protocadherin beta 14
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Plasma Membrane Membrane Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding	Calcium Ion Binding Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Chemical Synaptic Transmission Nervous System Development Synapse Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ	16 interacting genes: AKAP8L GOLGA6L9 HNRNPK HNRNPR KHDRBS3 KRT27 KRTAP6-3 MTUS2 PSTPIP1 PURB RBMX RBMY1A1 RBMY1F RBMY1J SRSF3 TRA2B
Entrez ID		6428	56122
HPRD ID		04530	06958
Ensembl ID		ENSG00000112081	ENSG00000120327
Uniprot IDs		B2R6F3 P84103	Q9Y5E9
PDB IDs		2I2Y 2I38 9ASQ
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex	MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process Regulation Of RNA Splicing RNA Processing MRNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex Regulation Of MRNA Metabolic Process Positive Regulation Of RNA Splicing Nucleic Acid Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Binding Positive Regulation Of MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Nucleoplasm RNA Splicing, Via Transesterification Reactions Protein Domain Specific Binding Regulation Of RNA Metabolic Process Catalytic Step 2 Spliceosome Pre-mRNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Ribonucleoprotein Complex Identical Protein Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Protein-RNA Sequence-specific Adaptor Activity Cyclin K-CDK12 Complex Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Supraspliceosomal Complex Nuclear Cyclin-dependent Protein Kinase Holoenzyme Complex Positive Regulation Of Low-density Lipoprotein Particle Clearance Purine-rich Negative Regulatory Element Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Macromolecule Metabolic Process
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