SRSF3 and RBM3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SRSF3	RBM3
Name		serine and arginine rich splicing factor 3	RNA binding motif protein 3
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Large Ribosomal Subunit Dendrite Cell Projection
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding	Nucleic Acid Binding RNA Binding Protein Binding Ribosomal Large Subunit Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor	RNA Processing Regulation Of Translation Positive Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination	None
GWAS		Glaucoma (primary open-angle) ( 33627673 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: KDM6A
Interacting Genes		40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ	18 interacting genes: CEBPA CHTOP HNRNPA0 HNRNPLL HNRNPR IL7R KHDRBS2 KHDRBS3 MYPOP PCBP1 PRR3 RBMX RBMY1A1 RBMY1F RBMY1J RBPMS2 SNRPA SRSF3
Entrez ID		6428	5935
HPRD ID		04530	02067
Ensembl ID		ENSG00000112081	ENSG00000102317
Uniprot IDs		B2R6F3 P84103	P98179
PDB IDs		2I2Y 2I38 9ASQ	7EB1
GO Terms Enriched among Interactors		Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex	Nucleic Acid Binding MRNA Binding MRNA Processing Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of MRNA Processing MRNA Metabolic Process Regulation Of MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Metabolic Process RNA Processing Positive Regulation Of RNA Splicing Nucleic Acid Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex RNA Splicing Nucleobase-containing Compound Metabolic Process Nucleoplasm Ribonucleoprotein Complex Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MRNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Identical Protein Binding Nucleolus Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Protein Domain Specific Binding Response To Vitamin B2 C/EBP Complex Interleukin-7 Receptor Activity Sequence-specific Single Stranded DNA Binding Protein-RNA Sequence-specific Adaptor Activity Positive Regulation Of Helicase Activity MRNA Export From Nucleus CHOP-C/EBP Complex Supraspliceosomal Complex Positive Regulation Of Macromolecule Metabolic Process RNA Export From Nucleus