SFRP4 and BUB1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		SFRP4	BUB1
Description		secreted frizzled related protein 4	BUB1 mitotic checkpoint serine/threonine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cell Surface	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Cytosol Membrane
	Molecular Function	Protein Binding Wnt-protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity Histone H2A Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport	Chromatin Remodeling Apoptotic Process Chromosome Segregation Regulation Of Sister Chromatid Cohesion Mitotic Spindle Assembly Checkpoint Signaling Intracellular Signal Transduction Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Chromosome Segregation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		Cyclothiazide Perindopril
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829 28886342) ghrelin levels ( 33852427) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		22 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4 SNCA	64 interacting genes: AKT1 ALDOB ANP32B AOPEP AP1B1 AP2B1 AP3B1 AP4B1 APC ARIH2 BAAT BUB3 CCDC180 CDC14B CDC20 CDK1 CDK8 CORO2A CRK CTSV CYLC2 DVL1 EIF4EBP1 FANCC FBP1 FBP2 FBXO7 FRAT2 GALNT12 HDAC1 HEMGN HRAS HSD17B3 IGFBP3 KNL1 LEF1 MAP2K1 MAPK3 MSANTD3 NANS PLK1 PPP2CB PPP3R2 RAE1 RASA1 RDH12 SEC61B SFRP2 SFRP4 SHC1 SMAD1 STX17 SVIL TBC1D2 TDRD7 TGFB1 TMEFF1 TMOD1 TRMO TSTD2 UBC XPA ZNF189 ZNF510
Entrez ID		6424	699
HPRD ID		07357	03907
Ensembl ID		ENSG00000106483	ENSG00000169679
Uniprot IDs		Q6FHJ7	B4DYG2 O43683
PDB IDs			2LAH 4A1G 4QPM 4R8Q 5DMZ 6F7B 7B1F 7B1H 7B1J
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Growth Factor Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Cell Population Proliferation Mesendoderm Development Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Growth Negative Regulation Of Locomotion Chemical Homeostasis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Protein Localization Gamma-catenin Binding Regulation Of Cellular Component Organization Axis Specification Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cytosol Cardiac Conduction System Development Nucleotide Binding Phosphate-containing Compound Metabolic Process Odontogenesis ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ruffle Membrane Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Development Gland Development Regulation Of T Cell Differentiation In Thymus Animal Organ Morphogenesis Disordered Domain Specific Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Development	Clathrin Adaptor Complex Regulation Of Organelle Organization Regulation Of Cellular Component Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Membrane Coat Cytosol Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Fructose 1,6-bisphosphate Metabolic Process Regulation Of Sister Chromatid Segregation Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Cytoskeleton Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Sister Chromatid Separation Canonical Wnt Signaling Pathway Regulation Of Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Separation Regulation Of Chromosome Segregation Insulin Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Protein Localization To Kinetochore Positive Regulation Of Ubiquitin-protein Transferase Activity Phosphoric Ester Hydrolase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Golgi Inheritance Negative Regulation Of Mitotic Nuclear Division Intracellular Signal Transduction Fructose Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Localization Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Protein Localization Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Regulation Of Chromosome Organization Positive Regulation Of Protein Localization Protein Kinase Binding Regulation Of Protein Localization To Membrane Gluconeogenesis Schwann Cell Development Negative Regulation Of Cell Cycle
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