SFRP4 and DLC1

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		SFRP4	DLC1
Description		secreted frizzled related protein 4	DLC1 Rho GTPase activating protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cell Surface	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Caveola Focal Adhesion Membrane Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft Anchoring Junction
	Molecular Function	Protein Binding Wnt-protein Binding	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport	Neural Tube Closure Heart Morphogenesis Signal Transduction Negative Regulation Of Cell Population Proliferation Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle
Drugs		Cyclothiazide Perindopril
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829 28886342) ghrelin levels ( 33852427) Heel bone mineral density ( 28869591 30598549)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels in HIV infection ( 33109212) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Mild obesity-related type 2 diabetes ( 34737425) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		22 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4 SNCA	35 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510
Entrez ID		6424	10395
HPRD ID		07357	05035
Ensembl ID		ENSG00000106483	ENSG00000164741
Uniprot IDs		Q6FHJ7	A8K119 Q96QB1
PDB IDs			2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT 7TPB
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Growth Factor Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Cell Population Proliferation Mesendoderm Development Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Growth Negative Regulation Of Locomotion Chemical Homeostasis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Protein Localization Gamma-catenin Binding Regulation Of Cellular Component Organization Axis Specification Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cytosol Cardiac Conduction System Development Nucleotide Binding Phosphate-containing Compound Metabolic Process Odontogenesis ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ruffle Membrane Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Development Gland Development Regulation Of T Cell Differentiation In Thymus Animal Organ Morphogenesis Disordered Domain Specific Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Development	Phosphate-containing Compound Metabolic Process TORC1 Signaling Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of Cell Adhesion Negative Regulation Of Transport Glucose Metabolic Process Negative Regulation Of Cell Size Thiolester Hydrolase Activity Fructose 1,6-bisphosphate Metabolic Process Intracellular Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of TORC1 Signaling Regulation Of Transcription By RNA Polymerase II Regulation Of TOR Signaling Hexose Metabolic Process Regulation Of Mononuclear Cell Migration Negative Regulation Of Cell-substrate Adhesion Long-chain Fatty Acyl-CoA Hydrolase Activity Fructose 6-phosphate Metabolic Process Negative Regulation Of Immune Response To Tumor Cell Myelin Maintenance Fatty Acyl-CoA Hydrolase Activity Lens Fiber Cell Differentiation Positive Regulation Of Catalytic Activity Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Fibroblast Migration Monosaccharide Metabolic Process Regulation Of Exit From Mitosis
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