SFRP4 and PTPRJ

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		SFRP4	PTPRJ
Description		secreted frizzled related protein 4	protein tyrosine phosphatase receptor type J
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cell Surface	Immunological Synapse Extracellular Region Nucleoplasm Nucleolus Plasma Membrane Cell-cell Junction Cell Surface Membrane Nuclear Body Cell Junction Ruffle Membrane Specific Granule Membrane Cell Projection Extracellular Exosome Anchoring Junction
	Molecular Function	Protein Binding Wnt-protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Beta-catenin Binding Hydrolase Activity Phosphatase Activity Protein Kinase Binding Gamma-catenin Binding Cadherin Binding Mitogen-activated Protein Kinase Binding Delta-catenin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport	Angiogenesis Vasculogenesis Positive Regulation Of Cell-matrix Adhesion Immune System Process Signal Transduction Axon Guidance Heart Development Blood Coagulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Platelet Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Cytokine-mediated Signaling Pathway Hemopoiesis Regulation Of Cell Adhesion B Cell Differentiation Platelet Formation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration Positive Regulation Of Tumor Necrosis Factor Production Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Glucose Homeostasis Negative Regulation Of Vascular Permeability Negative Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Negative Regulation Of Insulin Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Oligodendrocyte Differentiation Positive Regulation Of Phagocytosis Positive Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Positive Regulation Of Cellular Component Organization Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Contact Inhibition Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Biological Quality Positive Regulation Of Intracellular Signal Transduction
Pathways			Phosphorylation of CD3 and TCR zeta chains Neutrophil degranulation Negative regulation of MET activity Negative regulation of FLT3
Drugs		Cyclothiazide Perindopril
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829 28886342) ghrelin levels ( 33852427) Heel bone mineral density ( 28869591 30598549)	Acute lymphoblastic leukemia (childhood) ( 22076464) Alanine aminotransferase levels ( 33547301) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Caffeine consumption from coffee or tea ( 33287642) D-dimer levels ( 21502573) Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549) Height ( 28552196 25282103 23563607) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31879980) Intraocular pressure ( 31798171 31959993 30054594 29785010 29617998 29235454 25173106) Kawasaki disease ( 33692975) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Offspring birth weight ( 31043758) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Serum metabolite concentrations in chronic kidney disease ( 33838163) Sleep duration (short sleep) ( 30846698)
Interacting Genes		22 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4 SNCA	37 interacting genes: ANP32B BAAT BAP1 CASC3 CNKSR1 CTNNB1 CTNND1 CYP17A1 EGFR EPSTI1 FANCC FBP1 HEMGN HOXC6 HRAS IL2RG JUP KLK7 KLK9 LAT LYPD3 MAP2K1 MET NANS NOP2 PDGFRB PLCG1 PPP2CB PPP3R2 PRDM14 RASA1 SDCBP SFRP4 TMEFF1 TRMO TSTD2 ZNF510
Entrez ID		6424	5795
HPRD ID		07357	02955
Ensembl ID		ENSG00000106483	ENSG00000149177
Uniprot IDs		Q6FHJ7	Q12913 Q9NPR5
PDB IDs			2CFV 2DLE 2NZ6 7U01 7U08
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Growth Factor Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Cell Population Proliferation Mesendoderm Development Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Growth Negative Regulation Of Locomotion Chemical Homeostasis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Protein Localization Gamma-catenin Binding Regulation Of Cellular Component Organization Axis Specification Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cytosol Cardiac Conduction System Development Nucleotide Binding Phosphate-containing Compound Metabolic Process Odontogenesis ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ruffle Membrane Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Development Gland Development Regulation Of T Cell Differentiation In Thymus Animal Organ Morphogenesis Disordered Domain Specific Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Catenin-TCF7L2 Complex Phospholipase C Activator Activity ERBB Signaling Pathway Cellular Response To Indole-3-methanol Positive Regulation Of MAPK Cascade Catenin Complex Cell Morphogenesis Protein Phosphatase Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Regulation Of Signal Transduction Response To Indole-3-methanol Cell-cell Junction Trachea Formation Regulation Of Blood Vessel Branching Regulation Of Calcium Ion Import Regulation Of Ras Protein Signal Transduction Positive Regulation Of Cell Migration Protein Tyrosine Kinase Activity Alpha-catenin Binding Phosphatase Binding Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Phosphorylation Vasculature Development Regulation Of Cell Motility Focal Adhesion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Transport Regulation Of Signaling Regulation Of Locomotion Negative Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Transport Intracellular Signaling Cassette Tube Morphogenesis Regulation Of MAPK Cascade Histone Methyltransferase Binding Regulation Of Cell Population Proliferation Ciliary Basal Body Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ras Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Adherens Junction
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