SFRP4 and PFKM

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		SFRP4	PFKM
Description		secreted frizzled related protein 4	phosphofructokinase, muscle
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cell Surface	Nucleus Cytoplasm Cytosol 6-phosphofructokinase Complex Membrane Apical Plasma Membrane Sperm Principal Piece
	Molecular Function	Protein Binding Wnt-protein Binding	Nucleotide Binding Catalytic Activity 6-phosphofructokinase Activity Protein Binding ATP Binding Phosphofructokinase Activity Kinase Activity Transferase Activity Kinase Binding Identical Protein Binding Metal Ion Binding Fructose Binding Fructose-6-phosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport	Glycogen Catabolic Process Fructose 6-phosphate Metabolic Process Glycolytic Process Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Insulin Secretion Glucose Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Cellular Homeostasis Carbohydrate Phosphorylation Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Glycolysis From Storage Polysaccharide Through Glucose-1-phosphate
Pathways			Glycolysis
Drugs		Cyclothiazide Perindopril
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829 28886342) ghrelin levels ( 33852427) Heel bone mineral density ( 28869591 30598549)	Glycated hemoglobin levels ( 34059833) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Immature fraction of reticulocytes ( 32888494) Longevity (90 years and older) ( 25199915) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Red blood cell count ( 32888494)
Interacting Genes		22 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4 SNCA	20 interacting genes: ATP6V0A4 CAV3 CEBPA DLC1 DYNLL1 FHL2 HGS LSM7 MAPK3 NDUFB2 NOS1 PCNA PDGFRL PFKL SFRP2 SFRP4 SIAH1 SUMO2 TEAD4 UBTD1
Entrez ID		6424	5213
HPRD ID		07357	01988
Ensembl ID		ENSG00000106483	ENSG00000152556
Uniprot IDs		Q6FHJ7	A0A024R0Y5 A0A0S2Z4I1 A0A2R8Y891 F8VTQ3 P08237
PDB IDs			4OMT
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Growth Factor Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Cell Population Proliferation Mesendoderm Development Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Growth Negative Regulation Of Locomotion Chemical Homeostasis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Protein Localization Gamma-catenin Binding Regulation Of Cellular Component Organization Axis Specification Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cytosol Cardiac Conduction System Development Nucleotide Binding Phosphate-containing Compound Metabolic Process Odontogenesis ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ruffle Membrane Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Development Gland Development Regulation Of T Cell Differentiation In Thymus Animal Organ Morphogenesis Disordered Domain Specific Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Development	Caveola Regulation Of Ubiquitin-dependent Protein Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Trabecula Formation Negative Regulation Of Signaling Negative Regulation Of Transport Negative Regulation Of Cell Communication Negative Regulation Of Potassium Ion Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Z Disc Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cell Development Myoblast Fusion Regulation Of Cell Communication Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Hematopoietic Stem Cell Proliferation Response To Hormone Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Canonical Wnt Signaling Pathway Wnt-protein Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding Cellular Developmental Process Sodium Channel Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Membrane Repolarization T-tubule Cardiac Muscle Cell Development Regulation Of Sodium Ion Transmembrane Transport Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Proteolysis Syncytium Formation By Plasma Membrane Fusion Negative Regulation Of Signal Transduction Negative Regulation Of Sarcomere Organization Cell-cell Fusion Regulation Of Signal Transduction By Receptor Internalization Cardiac Cell Development Syncytium Formation Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Cell Population Proliferation Regulation Of Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Response To Dexamethasone Positive Regulation Of Macromolecule Biosynthetic Process PCNA Complex
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