SFRP4 and NARF

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		SFRP4	NARF
Description		secreted frizzled related protein 4	nuclear prelamin A recognition factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cell Surface	Nucleus Lamin Filament Nuclear Lamina Nucleoplasm Nucleolus Nuclear Lumen
	Molecular Function	Protein Binding Wnt-protein Binding	Lamin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Positive Regulation Of Receptor Internalization Negative Regulation Of Cell Population Proliferation Response To Hormone Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Epidermal Cell Differentiation Phosphate Ion Homeostasis Canonical Wnt Signaling Pathway Bone Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Sodium-dependent Phosphate Transport
Pathways
Drugs		Cyclothiazide Perindopril
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829 28886342) ghrelin levels ( 33852427) Heel bone mineral density ( 28869591 30598549)	Change in neurofilament light levels ( 31295725) Glucocorticoid-induced osteonecrosis ( 26265699) Lung function ( 31902109)
Interacting Genes		22 interacting genes: AP2M1 AQP6 AURKA BMPR1A BUB1 CDKN2A CKMT1B CTNNA1 DLC1 ERBB2 HSD17B11 MCC NARF NRAS PDGFRL PFKM PIK3CA PMS2 PTPN12 PTPRJ SMAD4 SNCA	3 interacting genes: APP LMNA SFRP4
Entrez ID		6424	26502
HPRD ID		07357	05637
Ensembl ID		ENSG00000106483	ENSG00000141562
Uniprot IDs		Q6FHJ7	Q9UHQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To Growth Factor Carbohydrate Homeostasis Glucose Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Kinase Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Cell Population Proliferation Negative Regulation Of Immature T Cell Proliferation Negative Regulation Of Cell Population Proliferation Mesendoderm Development Regulation Of Apoptotic Process Regulation Of Transforming Growth Factor Beta2 Production Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of T Cell Differentiation In Thymus Regulation Of Growth Negative Regulation Of Locomotion Chemical Homeostasis Regulation Of Epithelial Cell Proliferation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Protein Localization Gamma-catenin Binding Regulation Of Cellular Component Organization Axis Specification Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Cytosol Cardiac Conduction System Development Nucleotide Binding Phosphate-containing Compound Metabolic Process Odontogenesis ATP Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ruffle Membrane Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Development Gland Development Regulation Of T Cell Differentiation In Thymus Animal Organ Morphogenesis Disordered Domain Specific Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Development	Positive Regulation Of Receptor Internalization Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Negative Regulation Of Wnt Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Positive Regulation Of Endocytosis Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Regulation Of Protein Localization To Nucleus Microtubule-based Process Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation Of Sodium-dependent Phosphate Transport Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Microtubule-based Transport Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament Nuclear Pore Localization Positive Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Sodium-dependent Phosphate Transport Determination Of Pancreatic Left/right Asymmetry Regulation Of Canonical Wnt Signaling Pathway
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