DNAJC1 and PLP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DNAJC1	PLP2
Description		DnaJ heat shock protein family (Hsp40) member C1	proteolipid protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endomembrane System Membrane Nuclear Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	ATPase Activator Activity DNA Binding Protein Binding Protein-folding Chaperone Binding	Protein Binding Monoatomic Ion Transmembrane Transporter Activity Chemokine Binding
	Biological Process	Regulation Of Translation Protein Folding Negative Regulation Of Proteolysis Regulation Of Protein Secretion Regulation Of Protein Metabolic Process	Monoatomic Ion Transport Chemotaxis Cytokine-mediated Signaling Pathway Monoatomic Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33339817) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 23535729 29059683) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Essential hypertension (time to event) ( 32589924) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Oily fish consumption ( 32066663) Ovarian cancer ( 23535730) Pork consumption ( 32066663) Raw vegetable consumption ( 32066663) Subcutaneous adipose tissue ( 26480920) Urinary albumin-to-creatinine ratio ( 31511532)	Platelet distribution width ( 32888494)
Interacting Genes		12 interacting genes: ABHD16A AGTRAP ATP6V0C CFTR CMTM7 CYP4F2 HSPA5 ITIH4 PLP2 SERPINA3 TMEM201 TNFRSF10C	79 interacting genes: AQP2 AQP3 AQP6 AQP8 ARFIP2 ARL13B ASGR2 ATP5PF BCAP31 BIK BNIP3 CCR1 CD53 CD79A CERS4 CIAO2A CLDN5 CLN8 CPLX4 CRB3 CREB3L1 CYB561 CYBC1 CYBRD1 DARS2 DLGAP4 DNAJC1 EBP ELOVL5 ELP1 EVI2A FAM209A FAM210B FATE1 FCER1G FKBP7 FNDC9 GPR151 GPX8 HSBP1L1 HSD17B11 HSD17B13 KASH5 LHFPL1 LHFPL5 LMNA LRRC4C MGST3 MUC1 NDRG4 PACC1 PDZK1IP1 PIGP PSCA PTGES PVR REEP4 RETREG3 RNF5 SAR1A SCN3B SGPL1 SHBG SLC10A6 SLC14A2 SLC18A1 SLC2A13 SLC35H1 SPG21 SPN THAP4 TM4SF19 TMEM14B TMEM31 TMEM51 TMEM79 TMPRSS2 TMX2 VKORC1
Entrez ID		64215	5355
HPRD ID		09922	02121
Ensembl ID		ENSG00000136770	ENSG00000102007
Uniprot IDs		Q96KC8	Q04941
PDB IDs		2CQQ 2CQR
Enriched GO Terms of Interacting Partners?		Multicellular Organismal-level Water Homeostasis Peptidase Inhibitor Activity Acute-phase Response Serine-type Endopeptidase Inhibitor Activity Acute Inflammatory Response Regulation Of Cellular PH Regulation Of PH Regulation Of Intracellular PH Membrane Protein-folding Chaperone Binding Endoplasmic Reticulum Endoplasmic Reticulum Membrane Positive Regulation Of Anion Channel Activity Positive Regulation Of Enamel Mineralization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Multicellular Organismal-level Chemical Homeostasis Positive Regulation Of Monoatomic Anion Transport Cerebellum Structural Organization Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Phosphatidylserine Catabolic Process Fatty Acid Derivative Metabolic Process Prostaglandin Catabolic Process Alpha-tocopherol Omega-hydroxylase Activity Negative Regulation Of Icosanoid Secretion Leukotriene B4 Catabolic Process 20-hydroxy-leukotriene B4 Omega Oxidase Activity Alkane 1-monooxygenase Activity 20-aldehyde-leukotriene B4 20-monooxygenase Activity Leukotriene B4 Metabolic Process Arachidonate Omega-hydroxylase Activity Leukotriene-B4 20-monooxygenase Activity Pressure Natriuresis Angiotensin Type II Receptor Activity B-1a B Cell Differentiation B-1 B Cell Differentiation Nuclear Migration Along Microtubule Blood Microparticle Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Transepithelial Water Transport Monoacylglycerol Catabolic Process Vitamin E Metabolic Process Menaquinone Catabolic Process TRAIL Binding Multicellular Organismal-level Homeostasis Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Tooth Mineralization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Water Transport Renal Water Transport One-carbon Compound Transport Urea Transmembrane Transport Urea Transport Fluid Transport PH-gated Chloride Channel Activity Mitochondrial Membrane Channel Activity Apical Plasma Membrane Ascorbate Homeostasis Steroid Dehydrogenase Activity Organic Hydroxy Compound Transport Endoplasmic Reticulum-autophagosome Adaptor Activity Transmembrane Monodehydroascorbate Reductase Activity Glutathione Peroxidase Activity Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Transmembrane Transport Urea Transmembrane Transporter Activity Identical Protein Binding Glycerol Transmembrane Transport Plasma Membrane Substrate Localization To Autophagosome Ammonium Channel Activity Polyol Transmembrane Transport
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