DNAJC1 and ITIH4

Number of citations of the paper that reports this interaction (PMID 16271702)
2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DNAJC1	ITIH4
Gene Name		DnaJ (Hsp40) homolog, subfamily C, member 1	inter-alpha-trypsin inhibitor heavy chain family, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Extracellular Region Cytoplasm Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	ATPase Activator Activity DNA Binding Chromatin Binding Protein Binding Chaperone Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Regulation Of Translation Protein Folding Positive Regulation Of ATPase Activity Negative Regulation Of Proteolysis Regulation Of Protein Secretion	Acute-phase Response Negative Regulation Of Endopeptidase Activity Hyaluronan Metabolic Process Response To Cytokine
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Ovarian cancer ( 23535730)	Bipolar disorder ( 21926972) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 21926974) Ulcerative colitis ( 23128233)
Protein-Protein Interactions		4 interactors: ABHD16A HSPA5 ITIH4 SERPINA3	3 interactors: DNAJC1 GRB2 TP63
Entrez ID		64215	3700
HPRD ID		09922	02781
Ensembl ID		ENSG00000136770	ENSG00000055955
Uniprot IDs		Q96KC8	B2RMS9 B7ZKJ8 Q14624
PDB IDs		2CQQ 2CQR
Enriched GO Terms of Interacting Partners?		Acute-phase Response Acute Inflammatory Response Regulation Of Protein Folding In Endoplasmic Reticulum Cerebellum Structural Organization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity ER Overload Response Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Maintenance Of Protein Localization In Endoplasmic Reticulum Inflammatory Response Regulation Of Cellular Protein Metabolic Process Maintenance Of Gastrointestinal Epithelium Regulation Of Protein Metabolic Process Cellular Response To Antibiotic Epithelial Structure Maintenance Anatomical Structure Arrangement Regulation Of Catalytic Activity Cellular Response To Toxic Substance Cellular Response To Glucose Starvation Regulation Of Proteolysis Response To Cytokine Cerebellar Purkinje Cell Layer Development Negative Regulation Of Catalytic Activity Substantia Nigra Development Hyaluronan Metabolic Process ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Toxin Transport Cellular Response To Interleukin-4 Negative Regulation Of Protein Metabolic Process Response To Interleukin-4 Cerebellum Morphogenesis Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Neural Nucleus Development Hindbrain Morphogenesis Positive Regulation Of Nuclease Activity Response To Antibiotic Response To Stress Cerebellar Cortex Development Platelet Degranulation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway	Signal Transduction In Response To DNA Damage Cellular Response To Radiation Response To Ionizing Radiation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epidermal Cell Division Female Genitalia Morphogenesis Aging Cloacal Septation Urinary Bladder Development Positive Regulation Of Fibroblast Apoptotic Process Cloaca Development Prostatic Bud Formation Negative Regulation Of Keratinocyte Differentiation Negative Regulation Of Mesoderm Development Positive Regulation Of Keratinocyte Proliferation Polarized Epithelial Cell Differentiation Protein Oligomerization Response To Radiation Replicative Cell Aging Negative Regulation Of Cellular Senescence Lateral Sprouting From An Epithelium Negative Regulation Of Epidermal Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Reproductive Structure Development Reproductive System Development Morphogenesis Of An Epithelium DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of Cell Aging Regulation Of Body Fluid Levels Keratinocyte Proliferation Establishment Of Skin Barrier Establishment Of Planar Polarity Embryonic Morphogenesis Tissue Morphogenesis Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Proteolysis Genitalia Morphogenesis Regulation Of Water Loss Via Skin Post-anal Tail Morphogenesis Regulation Of Fibroblast Apoptotic Process Developmental Process Involved In Reproduction Regulation Of Keratinocyte Proliferation Labyrinthine Layer Morphogenesis Female Genitalia Development Sympathetic Nervous System Development
Tagcloud ?		10p12 af10 blasts bmi1 break calm centromeric comm commd3 enrichment gives homolog hsp40 immediately insertion leukemias leukemic lymphoblastic mlv mo p12 q14 recurring semiquantitative spag6 sperm striking subfamily transcriptase	arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih3 kilobase opposite pair rounds shares transcribed trypsin
Tagcloud (Difference) ?		10p12 af10 blasts bmi1 break calm centromeric comm commd3 enrichment gives homolog hsp40 immediately insertion leukemias leukemic lymphoblastic mlv mo p12 q14 recurring semiquantitative spag6 sperm striking subfamily transcriptase	arranged borders ccaat consists cotransfection direction dnase duplication ebp ebpalpha ebpbeta exon exons footprinting h1 heavy hepg2 intron inversion itih1 itih3 kilobase opposite pair rounds shares transcribed trypsin
Tagcloud (Intersection) ?