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PRKAR1A and SETD7
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
PRKAR1A
SETD7
Description
protein kinase cAMP-dependent type I regulatory subunit alpha
SET domain containing 7, histone lysine methyltransferase
Image
GO Annotations
Cellular Component
Immunological Synapse
Cytoplasm
Multivesicular Body
Centrosome
Cytosol
Plasma Membrane
Axoneme
CAMP-dependent Protein Kinase Complex
Membrane
Nucleotide-activated Protein Kinase Complex
Neuromuscular Junction
Protein-containing Complex
Plasma Membrane Raft
Synapse
Ciliary Base
Glutamatergic Synapse
Sperm Head-tail Coupling Apparatus
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Molecular Function
Nucleotide Binding
CAMP-dependent Protein Kinase Inhibitor Activity
Protein Binding
CAMP-dependent Protein Kinase Regulator Activity
Protein Domain Specific Binding
CAMP Binding
Ubiquitin Protein Ligase Binding
Protein Kinase A Catalytic Subunit Binding
P53 Binding
Chromatin Binding
Protein Binding
Methyltransferase Activity
Protein-lysine N-methyltransferase Activity
Transferase Activity
Histone Methyltransferase Activity
Histone H3 Methyltransferase Activity
Histone H3K4 Monomethyltransferase Activity
Biological Process
Mesoderm Formation
Regulation Of Transcription By RNA Polymerase II
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Heart Development
Negative Regulation Of Gene Expression
Positive Regulation Of Insulin Secretion
Intracellular Signal Transduction
Sarcomere Organization
Negative Regulation Of Activated T Cell Proliferation
Cardiac Muscle Cell Proliferation
Cellular Response To Glucagon Stimulus
Negative Regulation Of CAMP/PKA Signal Transduction
Regulation Of DNA Repair
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
DNA Damage Response
Peptidyl-lysine Monomethylation
Peptidyl-lysine Dimethylation
Methylation
Response To Ethanol
Positive Regulation Of DNA-templated Transcription
Heterochromatin Organization
Response To Alcohol
Pathways
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
CREB1 phosphorylation through the activation of Adenylate Cyclase
Hedgehog 'off' state
GPER1 signaling
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis
ALK mutants bind TKIs
Signaling by ALK fusions and activated point mutants
Factors involved in megakaryocyte development and platelet production
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
PKMTs methylate histone lysines
Drugs
(Rp)-cAMPS
Cyclic GMP
Cyclic adenosine monophosphate
GEM-231
S-adenosyl-L-homocysteine
Diseases
Pigmented micronodular adrenocortical disease (PPNAD)
GWAS
Body size at age 10 (
32376654
)
Coronary artery disease (
33020668
)
Estimated glomerular filtration rate (
31152163
)
Intake of total sugars (
31005972
)
Serum alkaline phosphatase levels (
33547301
)
Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) (
29097388
)
Ferritin levels (
33491795
)
Lean body mass (
28552196
)
Salty taste perception in obesity with metabolic syndrome (
31005965
)
Serum lycopene concentrations (
26861389
)
Interacting Genes
55 interacting genes:
AKAP1
AKAP10
AKAP11
AKAP19
AKAP4
AKAP5
AKAP7
AKT1
ARFGEF2
BAHD1
BTG3
CAPN11
CBS
CCNE1
CDK2
CDK4
CSTPP1
DSCR4
DSCR9
DTX1
EGFR
FAM153B
GRB2
HIVEP1
HLA-A
ITGA4
MAP1A
MAP1B
MAPK6
MYO7A
NELL2
OGT
PATZ1
PJA2
PLEKHF2
PRKACA
PRKAR1B
PRKX
PRPF40A
PSMG1
PYCARD
RAF1
RFC2
RSPH3
SET
SETD7
SLC2A4
SMAD2
SNCA
SPART
TAB1
WDCP
WNK1
YWHAZ
ZBED1
32 interacting genes:
A1BG
ATG16L1
DNMT1
E2F1
ESR1
H3-3A
H3-4
H3C1
H3C14
H4C1
HCFC1
KLF4
L3MBTL1
MDM2
NR2F2
OGT
OTUB1
PPP1R12A
PRKAR1A
RELA
RIOK1
SERTAD1
SIRT1
SMAD7
SOX2
STAT3
STEAP3
TAF10
TAF7
TP53
TRIM21
UBC
Entrez ID
5573
80854
HPRD ID
01786
16226
Ensembl ID
ENSG00000108946
ENSG00000145391
Uniprot IDs
B2R5T5
P10644
B5MCZ8
D6RJA0
Q8WTS6
PDB IDs
5KJX
5KJY
5KJZ
1H3I
1MT6
1MUF
1N6A
1N6C
1O9S
1XQH
2F69
3CBM
3CBO
3CBP
3M53
3M54
3M55
3M56
3M57
3M58
3M59
3M5A
3OS5
3VUZ
3VV0
4E47
4J7F
4J7I
4J83
4J8O
4JDS
4JLG
5AYF
5EG2
5YLT
Enriched GO Terms of Interacting Partners
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Protein Kinase A Regulatory Subunit Binding
CAMP-dependent Protein Kinase Complex
Protein Kinase A Binding
Protein Phosphorylation
Cytosol
Phosphorylation
Protein-containing Complex
Ubiquitin Protein Ligase Binding
Cytoplasm
Peptidyl-serine Phosphorylation
Regulation Of Protein Localization To Cell Periphery
Protein Serine Kinase Activity
Intracellular Signal Transduction
Regulation Of Biological Quality
Signal Transduction
Kinase Activity
Protein Kinase Activity
Cyclin E1-CDK2 Complex
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Serine/threonine Kinase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
TORC1 Signaling
Regulation Of Lymphocyte Migration
Intracellular Signaling Cassette
Postsynapse
Cellular Response To Oxygen-containing Compound
Protein Kinase Binding
Intracellular Protein Localization
Protein Domain Specific Binding
Cell Surface Receptor Signaling Pathway
Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Protein Localization To Cell Periphery
ERBB Signaling Pathway
Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
CAMP-dependent Protein Kinase Activity
Establishment Of Protein Localization
TOR Signaling
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Protein Catabolic Process
Negative Regulation Of Catabolic Process
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of T Cell Migration
Odontoblast Differentiation
Regulation Of Protein Kinase A Signaling
Organelle Organization
Regulation Of Leukocyte Cell-cell Adhesion
Regulation Of Protein Localization To Membrane
Enzyme Binding
Chromatin Organization
Nucleoplasm
Negative Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein-containing Complex
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Regulator Complex
Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Chromatin Remodeling
Protein-DNA Complex Assembly
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Gene Expression
DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Promoter-specific Chromatin Binding
Positive Regulation Of Biosynthetic Process
Regulation Of MiRNA Transcription
Chromatin
DNA Binding
Regulation Of Cell Differentiation
Nucleobase-containing Compound Biosynthetic Process
Regulation Of Developmental Process
Transcription Cis-regulatory Region Binding
Structural Constituent Of Chromatin
Chromatin DNA Binding
Regulation Of MiRNA Metabolic Process
Negative Regulation Of Signal Transduction
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