PRKAR1A and PYCARD

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRKAR1A	PYCARD
Description		protein kinase cAMP-dependent type I regulatory subunit alpha	PYD and CARD domain containing
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus	Golgi Membrane Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule IkappaB Kinase Complex Membrane Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Neuronal Cell Body Canonical Inflammasome Complex NLRP1 Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex NLRP6 Inflammasome Complex
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protease Binding Interleukin-6 Receptor Binding Protein Binding Tropomyosin Binding Myosin I Binding Enzyme Binding Pyrin Domain Binding Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Dimerization Activity BMP Receptor Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction	Myeloid Dendritic Cell Activation Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Defense Response To Virus By Host Myeloid Dendritic Cell Activation Involved In Immune Response Immune System Process Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Positive Regulation Of Adaptive Immune Response Apoptotic Process Inflammatory Response Signal Transduction Osmosensory Signaling Pathway Response To Bacterium Regulation Of Autophagy Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Actin Filament Polymerization Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Positive Regulation Of Chemokine Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Macropinocytosis NLRP3 Inflammasome Complex Assembly Innate Immune Response Positive Regulation Of JNK Cascade Icosanoid Biosynthetic Process Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Positive Regulation Of Macrophage Cytokine Production Pyroptotic Inflammatory Response Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Protein Serine/threonine Kinase Activity Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Canonical Inflammasome Complex Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Migration Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	CLEC7A/inflammasome pathway Neutrophil degranulation The NLRP3 inflammasome The AIM2 inflammasome Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses
Drugs		(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)	Post bronchodilator FEV1 ( 26634245)
Interacting Genes		55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1	15 interacting genes: CASP1 EXOC5 MEFV NLRC4 NLRP1 NLRP12 NLRP3 POP1 PRKAR1A PYDC2 RUBCN SRF USP3 USP50 ZFYVE21
Entrez ID		5573	29108
HPRD ID		01786	06020
Ensembl ID		ENSG00000108946	ENSG00000103490
Uniprot IDs		B2R5T5 P10644	Q9ULZ3
PDB IDs		5KJX 5KJY 5KJZ	1UCP 2KN6 3J63 5H8O 6K99 6KI0 6N1H 7E5B 7KEU
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Canonical Inflammasome Complex Pyroptotic Inflammatory Response Regulation Of Interleukin-18 Production Positive Regulation Of Inflammatory Response NLRP3 Inflammasome Complex Regulation Of Inflammatory Response Negative Regulation Of Interleukin-1 Production Regulation Of NLRP3 Inflammasome Complex Assembly Cysteine-type Endopeptidase Activator Activity Positive Regulation Of Interleukin-18 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Defense Response IPAF Inflammasome Complex Regulation Of Defense Response Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Inflammatory Response Positive Regulation Of Innate Immune Response Immune System Process Immune Response-activating Signaling Pathway NLRP1 Inflammasome Complex Negative Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Osmosensory Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Positive Regulation Of Gene Expression Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Interleukin-18-mediated Signaling Pathway Pyroptotic Cell Death Negative Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Defense Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Innate Immune Response Negative Regulation Of Cytokine Production Positive Regulation Of Immune Response Cysteine-type Peptidase Activity Response To Other Organism
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