PRKAR1A and AKAP11

Number of citations of the paper that reports this interaction (PubMedID 10864471)
0

Data Source:
HPRD (in vivo)

		PRKAR1A	AKAP11
Description		protein kinase cAMP-dependent type I regulatory subunit alpha	A-kinase anchoring protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus	Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Binding Protein Phosphatase 1 Binding Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding
	Biological Process	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction	Renal Water Homeostasis Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Intracellular Protein Localization Cortical Actin Cytoskeleton Organization Intracellular Signal Transduction Protein Localization To Endosome
Pathways		PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Asthma (childhood onset) ( 30929738) Bone mineral density ( 24249740) Bone mineral density (spine) ( 19801982) Crohn's disease ( 28067908) Hepcidin levels ( 27846281) Inflammatory bowel disease ( 28067908) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (drugs affecting bone structure and mineralization) ( 31015401) Medication use (thyroid preparations) ( 31015401) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Serum alkaline phosphatase levels ( 33339817 33547301) Type 1 diabetes ( 34012112 34127860)
Interacting Genes		55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1	8 interacting genes: GSK3A GSK3B PPP1CA PPP1CC PRKAR1A PRKAR2A PRKAR2B WEE2-AS1
Entrez ID		5573	11215
HPRD ID		01786	05261
Ensembl ID		ENSG00000108946	ENSG00000023516
Uniprot IDs		B2R5T5 P10644	Q9UKA4
PDB IDs		5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding	Protein Kinase A Catalytic Subunit Binding CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Glycogen Metabolic Process Energy Reserve Metabolic Process Polysaccharide Metabolic Process Postsynapse CAMP Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Metabolic Process Ciliary Base Regulation Of Glycogen (starch) Synthase Activity Regulation Of CAMP/PKA Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Protein Domain Specific Binding Glutamatergic Synapse Cellular Response To Interleukin-3 PTW/PP1 Phosphatase Complex Rhythmic Process Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Generation Of Precursor Metabolites And Energy Nucleotide-activated Protein Kinase Complex Beta-catenin Destruction Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Circadian Rhythm Carbohydrate Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Circadian Rhythm Tau-protein Kinase Activity Dendritic Spine Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Phosphatase 1 Binding Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Photoperiodism Entrainment Of Circadian Clock Positive Regulation Of Membrane Permeability Plasma Membrane Raft Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Presynapse
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