GZMK and SET

Number of citations of the paper that reports this interaction (PubMedID 20876349)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study)

		GZMK	SET
Description		granzyme K	SET nuclear proto-oncogene
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Symbiont Cell Surface	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Pattern Recognition Receptor Activity	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding
	Biological Process	Activation Of Membrane Attack Complex Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Inflammatory Response Protein Maturation Positive Regulation Of Release Of Cytochrome C From Mitochondria Granzyme-mediated Programmed Cell Death Signaling Pathway Complement Activation, GZMK Pathway	DNA Replication Nucleosome Assembly Nucleosome Disassembly Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription
Pathways			Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP	69 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4C14 H4C16 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NEDD8 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UBE3A UCHL5 XRCC6 ZNF17 ZNF438 ZNF85
Entrez ID		3003	6418
HPRD ID		02872	09023
Ensembl ID		ENSG00000113088	ENSG00000119335
Uniprot IDs		P49863	A0A8J8YYJ1 Q01105 Q5VXV3
PDB IDs		1MZA 1MZD	2E50 7MTO
Enriched GO Terms of Interacting Partners?		VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of RIG-I Signaling Pathway Damaged DNA Binding Double-strand Break Repair Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process DNA Repair Cellular Response To Misfolded Protein Regulation Of Programmed Cell Death Response To Misfolded Protein ERAD Pathway Base-excision Repair, Gap-filling Nucleus Ubiquitin Protein Ligase Binding V(D)J Recombination Regulation Of RIG-I Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Macromolecule Metabolic Process Organelle Organization DNA Damage Response Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Apoptotic Process Condensed Chromosome Regulation Of Metabolic Process Base-excision Repair Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Somatic Cell DNA Recombination Negative Regulation Of Type I Interferon Production Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Basal Body Patch Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To Stress Telomere Maintenance Via Base-excision Repair	Nucleus DNA Binding Chromosome Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Telomere Organization Chromosome, Telomeric Region Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Organization Regulation Of Multicellular Organismal Process Chromatin Remodeling Regulation Of Gene Expression Regulation Of Phosphorus Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of ATP Metabolic Process Double-stranded Telomeric DNA Binding Nuclear Telomere Cap Complex Regulation Of Purine Nucleotide Metabolic Process Nucleosome Organization Regulation Of Developmental Process Protein-DNA Complex Assembly Regulation Of Glycolytic Process Regulation Of Cell Cycle Regulation Of Carbohydrate Catabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Programmed Cell Death Protein-DNA Complex Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process
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