GZMK and TUBB3

Number of citations of the paper that reports this interaction (PubMedID 19059912)
0

Data Source:
BioGRID (enzymatic study)

		GZMK	TUBB3
Description		granzyme K	tubulin beta 3 class III
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Symbiont Cell Surface	Nucleus Cytoplasm Cytoskeleton Microtubule Microtubule Cytoskeleton Lamellipodium Filopodium Axon Dendrite Growth Cone Cell Projection Neuronal Cell Body Intercellular Bridge Extracellular Exosome Cell Periphery Mitotic Spindle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Pattern Recognition Receptor Activity	Nucleotide Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Peptide Binding Metal Ion Binding Netrin Receptor Binding
	Biological Process	Activation Of Membrane Attack Complex Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Inflammatory Response Protein Maturation Positive Regulation Of Release Of Cytochrome C From Mitochondria Granzyme-mediated Programmed Cell Death Signaling Pathway Complement Activation, GZMK Pathway	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs			Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases			Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Blood protein levels ( 30072576)	Brain morphology (MOSTest) ( 32665545) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP	38 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDC42 CDKN1A DDX39B DUX4 EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 LINC01554 MAP7D3 MAPT MRPL28 MTCL1 MTDH OGT PHIP PLK1 RCC1 RILPL2 ROBO1 RSPH1 SCGN SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE WEE2-AS1
Entrez ID		3003	10381
HPRD ID		02872	04044
Ensembl ID		ENSG00000113088	ENSG00000258947
Uniprot IDs		P49863	Q13509 Q53G92
PDB IDs		1MZA 1MZD	5IJ0 5IJ9 5JCO 6E7B 6S8L 6WSL 7LXB 7M18 7M20 7PJF 7SJ7 7SJ8 7SJ9 7SJA 7Z6S 8VRJ 8VRK 8VT7
Enriched GO Terms of Interacting Partners?		VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of RIG-I Signaling Pathway Damaged DNA Binding Double-strand Break Repair Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process DNA Repair Cellular Response To Misfolded Protein Regulation Of Programmed Cell Death Response To Misfolded Protein ERAD Pathway Base-excision Repair, Gap-filling Nucleus Ubiquitin Protein Ligase Binding V(D)J Recombination Regulation Of RIG-I Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Macromolecule Metabolic Process Organelle Organization DNA Damage Response Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Apoptotic Process Condensed Chromosome Regulation Of Metabolic Process Base-excision Repair Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Somatic Cell DNA Recombination Negative Regulation Of Type I Interferon Production Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Basal Body Patch Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To Stress Telomere Maintenance Via Base-excision Repair	Microtubule Binding Regulation Of Protein-containing Complex Assembly Microtubule Cytoskeleton Organization Regulation Of Protein Localization To Synapse Regulation Of Cell Cycle Process Regulation Of Microtubule Cytoskeleton Organization Intercellular Canaliculus Regulation Of Protein K48-linked Ubiquitination Cytoskeleton Organization Microtubule-based Process Regulation Of Protein Modification Process Organelle Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Mitotic Nuclear Division Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Nuclear Division Regulation Of Microtubule-based Process Cellular Component Assembly Mitotic Cell Cycle Phase Transition
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