GZMK and NPLOC4

Number of citations: 0 (PubMedID 20876349)
Data Source: BioGRID (enzymatic study)

		GZMK	NPLOC4
Name		granzyme K	NPL4 homolog, ubiquitin recognition factor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Symbiont Cell Surface	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Glycosaminoglycan Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Pattern Recognition Receptor Activity	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding ATPase Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Activation Of Membrane Attack Complex Proteolysis Complement Activation Opsonization Zymogen Activation Killing Of Cells Of Another Organism Positive Regulation Of Inflammatory Response Protein Maturation Positive Regulation Of Release Of Cytochrome C From Mitochondria Granzyme-mediated Programmed Cell Death Signaling Pathway Complement Activation, GZMK Pathway	Ubiquitin-dependent Protein Catabolic Process Golgi Organization Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production ERAD Pathway Negative Regulation Of RIG-I Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		None	Translesion Synthesis by POLH Neddylation KEAP1-NFE2L2 pathway Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
GWAS		Blood protein levels ( 30072576 )	Advanced age-related macular degeneration ( 26691988 ) Cataracts ( 34127677 ) Cataracts (operation) ( 31816047 ) Central corneal thickness ( 32528159 ) Eye color traits ( 20463881 ) Intraocular pressure ( 29617998 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Myopia ( 27182965 ) Non-albumin protein levels ( 29403010 ) Optic disc size ( 31809533 ) Red blood cell count ( 27863252 32888494 ) Red cell distribution width ( 28957414 32888494 27863252 ) Refractive astigmatism ( 30306274 ) Refractive error ( 32231278 )
Interacting Genes		13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP	9 interacting genes: CDC42 ERCC6 GZMK MAP3K1 RAF1 TMUB1 UBC UFD1 VPS26B
Entrez ID		3003	55666
HPRD ID		02872	06975
Ensembl ID		ENSG00000113088	ENSG00000182446
Uniprot IDs		P49863	Q8TAT6
PDB IDs		1MZA 1MZD	7WWP 7WWQ
GO Terms Enriched among Interactors		VCP-NPL4-UFD1 AAA ATPase Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Retrograde Protein Transport, ER To Cytosol UFD1-NPL4 Complex Cellular Response To Topologically Incorrect Protein Protein Exit From Endoplasmic Reticulum Cellular Response To Stress DNA Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of RIG-I Signaling Pathway Damaged DNA Binding Double-strand Break Repair Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic Process DNA Repair Cellular Response To Misfolded Protein Regulation Of Programmed Cell Death Response To Misfolded Protein ERAD Pathway Base-excision Repair, Gap-filling Nucleus Ubiquitin Protein Ligase Binding V(D)J Recombination Regulation Of RIG-I Signaling Pathway Regulation Of Type I Interferon Production Regulation Of Macromolecule Metabolic Process Organelle Organization DNA Damage Response Negative Regulation Of RNA Splicing Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Apoptotic Process Condensed Chromosome Regulation Of Metabolic Process Base-excision Repair Negative Regulation Of Programmed Cell Death Macromolecule Metabolic Process Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Somatic Cell DNA Recombination Negative Regulation Of Type I Interferon Production Negative Regulation Of Biosynthetic Process Protein Domain Specific Binding Basal Body Patch Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Response To Stress Telomere Maintenance Via Base-excision Repair	Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Protein Metabolic Process MAP Kinase Kinase Kinase Activity MAPK Cascade Intracellular Protein Localization Intracellular Signaling Cassette GBD Domain Binding Storage Vacuole Phagocytic Vesicle Cellular Response To Type II Interferon Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Death-inducing Signaling Complex Assembly ERAD Pathway UFD1-NPL4 Complex Response To Type II Interferon