MCRS1 and ZRANB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MCRS1	ZRANB1
Description		microspherule protein 1	zinc finger RANBP2-type containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Lysosome Centrosome Cytoskeleton Nuclear Body Dendrite Ino80 Complex Centriolar Satellite Perikaryon NSL Complex MLL1 Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	G-quadruplex RNA Binding Protein Binding Poly(U) RNA Binding Telomerase Inhibitor Activity Poly(G) Binding	Catalytic Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Deubiquitinase Activity
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Protein Localization To Nucleolus	Autophagosome Assembly Proteolysis Cytoskeleton Organization Wnt Signaling Pathway Cell Migration Protein Deubiquitination Regulation Of Cell Morphogenesis Positive Regulation Of Wnt Signaling Pathway Protein K29-linked Deubiquitination Phosphatidylinositol Phosphate Biosynthetic Process Protein K63-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Protein K33-linked Deubiquitination
Pathways		HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes	Degradation of beta-catenin by the destruction complex Ovarian tumor domain proteases
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Creatine kinase levels ( 29403010) Height ( 25429064 31562340) Lung cancer ( 34062886)
Interacting Genes		125 interacting genes: AGGF1 ARK2N AXIN2 BACH2 BEND3 BHLHA9 BHLHE40 BLM BRD8 BRMS1 BRMS1L C7orf57 C8orf34 CARD9 CATSPERT CAVIN2 CBY2 CCDC13 CCDC136 CCDC85B CCHCR1 CCNH CDCA7L CEP44 CEP70 CNTROB COIL CREB3L3 CRYAA CYSRT1 CYTIP DAXX DRAP1 DSCR9 DVL2 EGR2 ERF EVI5 FAM9A FNDC8 FSD2 FXR1 FXR2 GAS7 GCC1 GEM GIGYF1 GOLGA2 GPBP1 HMBOX1 HOOK2 IKZF1 IKZF3 IKZF4 JAKMIP1 KANK2 KAT7 KDM1A KIAA1958 KRT35 KRTAP10-7 KRTAP2-3 KRTAP2-4 KXD1 LIG4 LSM6 LZTS1 MAGEA11 MAGEA6 MAPK9 MED4 MEOX1 MFAP1 MIER2 MIER3 NAA10 NAB2 NKAPD1 NOP2 OSBPL3 PBK PBX2 PCM1 PHC2 PIBF1 PINX1 PKNOX2 PPP1R13B PRMT5 PSTPIP1 PTEN RABEP1 RALYL RARA RETREG3 RIPPLY3 SH2B2 SHANK3 SNAPC5 SP4 SRRM4 SSMEM1 SUV39H1 TADA2B TBC1D1 TERT TFAP4 TLE5 TNIP1 TNNI1 TP63 TRIM37 TRIM41 TSPYL2 UPF3B USHBP1 WASHC3 WBP11 XIAP ZBTB22 ZCCHC12 ZNF23 ZNF639 ZNF8 ZRANB1	130 interacting genes: AKT1 ARHGEF5 ARRDC2 ARRDC3 ATOSB BAHD1 BRD1 C1orf35 CARD9 CBX7 CBX8 CCDC120 CCDC13 CCDC185 CCDC187 CCHCR1 CCNL1 CDC45 CDK18 CDKL3 CNNM3 CORO7 CPNE7 CWF19L2 DCX DNAJB13 DTNB DUSP13B ENKD1 FAIM FAM124B FAM161A FAM161B FAM50B FAM90A1 FNDC11 GADD45GIP1 GAS2L2 GEM GLIS2 GPANK1 HOXB5 HOXC8 IL16 INO80B IP6K3 IQUB JRK KANK2 KIF9 KIFC3 LENG1 LMO3 LNX1 MAGEB4 MAGOH MCRS1 METTL21A MID2 MPPED1 MYEF2 NEK6 NUDT16L1 PHF1 PHF19 PKN1 PLEKHN1 PNMA5 POLDIP3 POLL PPP1R18 PSPC1 RAPGEF3 RASAL3 SCNM1 SDCBP SLC7A11 SNCA STAMBPL1 SUV39H1 SYT17 SYTL4 TBC1D3 TBC1D30 TBC1D3B TBC1D3C TBC1D3G TBC1D3K TCEANC THAP7 TIE1 TLE5 TNS4 TRAF3IP3 TRAF4 TRAF6 TRAPPC2 TRAPPC2B TSGA10IP TSPYL4 TSTD2 TTC23 TWIST1 UBASH3A UBC UBE2D1 UBE2G1 USP2 UVRAG VAV3 WT1 ZBTB24 ZBTB47 ZNF124 ZNF17 ZNF250 ZNF408 ZNF417 ZNF438 ZNF490 ZNF497 ZNF552 ZNF575 ZNF587 ZNF599 ZNF648 ZNF764 ZNF775 ZNF792 ZNF837
Entrez ID		10445	54764
HPRD ID		11298	11738
Ensembl ID		ENSG00000187778	ENSG00000019995
Uniprot IDs		Q96EZ8	Q9UGI0
PDB IDs			3ZRH 5AF6
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone Deacetylase Binding Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Protein-containing Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleolus Chromatin Binding Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Protein Domain Specific Binding Chromatin Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Stem Cell Proliferation Regulation Of Nervous System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Senescence Regulation Of Centromeric Sister Chromatid Cohesion MRF Binding Telomere Maintenance Via Telomerase Sequence-specific DNA Binding	Protein Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Zinc Ion Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Nuclear Speck Regulation Of Macromolecule Metabolic Process Microtubule Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process
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