MCRS1 and IKZF1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MCRS1	IKZF1
Gene Name		microspherule protein 1	IKAROS family zinc finger 1 (Ikaros)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleoplasm Nucleolus Cytoplasm Actin Cytoskeleton Cell Junction Ino80 Complex MLL1 Complex	Nucleus Pericentric Heterochromatin Cytoplasm Protein Complex
	Molecular Function	Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	DNA Repair DNA Recombination Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Protein Modification Process Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Natural Killer Cell Differentiation Transcription, DNA-templated Cell Cycle Mesoderm Development Chromatin Modification B Cell Differentiation T Cell Differentiation Forebrain Development Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Neutrophil Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Lymph Node Development Thymus Development Peyer's Patch Development Positive Regulation Of NK T Cell Differentiation Retina Development In Camera-type Eye
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23512250 19684603 19684604) Crohn's disease ( 21102463) Hippocampal atrophy ( 19668339) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 19862010) Red blood cell traits ( 23222517) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		30 interactors: BLM CCDC53 CCDC85B CEP44 DAXX DVL2 FXR2 GCC1 GPBP1 IKZF1 KDM1A KIAA1958 KXD1 LIG4 LSM6 MAGEA11 MED4 NOP2 PBX2 PHC2 PINX1 PRMT5 RALYL SUV39H1 TERT TRIM37 UPF3B USHBP1 WBP11 ZBTB22	75 interactors: AEN ALKBH3 ANKRD11 AP1M1 AP2M1 ARMC7 BYSL C19orf66 C1orf109 C1orf174 C8orf33 CBX8 CDK2AP2 CEP57L1 CHD3 CKS1B CSNK1G1 CTBP1 CTBP2 DCX DDX6 DYRK2 FAM161A FAM214B FAM50B FAM74A4 FGF12 FRMD6 GLRX3 GMCL1P1 GTF2B HDAC1 HDAC2 IKZF2 IKZF3 IKZF4 IKZF5 ISCU KIF9 LMO3 LSM4 MAD2L2 MCRS1 MORF4L1 MORF4L2 MTA1 NEK6 NOC4L NUDT21 PIN1 PNKP PRKAB2 PSMA1 PSMA4 RAD51D RBBP8 RWDD2B SAP18 SCNM1 SDCBP SH2D4A SIN3A SIN3B SMARCA4 SNRPF SNW1 SPATC1L SYT17 TBP TDG UBE2I WTAP ZMAT2 ZNF417 ZNF581
Entrez ID		10445	10320
HPRD ID		11298	04318
Ensembl ID		ENSG00000187778	ENSG00000185811
Uniprot IDs		Q7Z372 Q96EZ8	Q13422
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Chromosome Organization Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Chromatin Modification Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Chromatin Organization RRNA Processing RRNA Metabolic Process Positive Regulation Of Gene Expression Ribonucleoprotein Complex Biogenesis Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Ribosome Biogenesis Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated NcRNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process DNA Replication RNA-dependent DNA Replication RNA Processing Positive Regulation Of Transcription, DNA-templated Leukocyte Differentiation RNA Splicing DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Response To X-ray T Cell Differentiation Histone Modification	RNA Metabolic Process Gene Expression Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Organelle Organization Chromosome Organization Chromatin Modification Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Negative Regulation Of Gene Expression Histone Deacetylation Protein Deacetylation Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Repair Regulation Of Cell Cycle Signal Transduction By P53 Class Mediator Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Metabolic Process Regulation Of Cell Cycle Phase Transition RNA Splicing
Tagcloud ?		acetylates akhtar buscaino duncan gebhardt h4k16 hcf1 holz ino80 mendjan mof moz msl mueller myst myst1 nsl nucleosomal relaxed sas2 sas3 saumweber schelder stunnenberg taipale vermeulen wdr5 wilm ybf2	agree china cnki cochrane databases deletion derive efs eligible embase estimation ethnicity hazard infrastructure intervals lymphoblastic meta methodology precise pubmed random ratios science stratified subgroups unfavorable updated wanfang web
Tagcloud (Difference) ?		acetylates akhtar buscaino duncan gebhardt h4k16 hcf1 holz ino80 mendjan mof moz msl mueller myst myst1 nsl nucleosomal relaxed sas2 sas3 saumweber schelder stunnenberg taipale vermeulen wdr5 wilm ybf2	agree china cnki cochrane databases deletion derive efs eligible embase estimation ethnicity hazard infrastructure intervals lymphoblastic meta methodology precise pubmed random ratios science stratified subgroups unfavorable updated wanfang web
Tagcloud (Intersection) ?