MCRS1 and PINX1

Number of citations of the paper that reports this interaction (PubMedID 15044100)
0

Data Source:
BioGRID (pull down)
HPRD (in vivo, two hybrid, in vitro)

		MCRS1	PINX1
Description		microspherule protein 1	PIN2 (TERF1) interacting telomerase inhibitor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Chromosome, Centromeric Region Kinetochore Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Lysosome Centrosome Cytoskeleton Nuclear Body Dendrite Ino80 Complex Centriolar Satellite Perikaryon NSL Complex MLL1 Complex	Nuclear Chromosome Chromosome, Centromeric Region Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Nucleolus Mitochondrion Spindle
	Molecular Function	G-quadruplex RNA Binding Protein Binding Poly(U) RNA Binding Telomerase Inhibitor Activity Poly(G) Binding	Nucleic Acid Binding Protein Binding Telomerase Inhibitor Activity Protein-containing Complex Binding Telomerase RNA Binding
	Biological Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Organization Chromatin Remodeling DNA Damage Response Positive Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Protein Localization To Nucleolus	Telomere Maintenance Via Telomerase Mitotic Metaphase Chromosome Alignment Negative Regulation Of Cell Population Proliferation Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Protein Localization To Nucleolus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Protein Localization To Nucleolus
Pathways		HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
GWAS			A body shape index ( 34021172) Adventurousness ( 30643258) Anxiety/tension (special factor of neuroticism) ( 30867560) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder ( 30804558) Brain morphology (MOSTest) ( 32665545) Carotid intima media thickness ( 30510157 21909108) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (beta diversity) ( 27723756) Lymphocyte count ( 27863252 32888494) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Retinal vascular caliber ( 21060863) Serum alkaline phosphatase levels ( 33547301) Systemic lupus erythematosus ( 26316170) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 28334899 32154731) Triglycerides ( 30275531 24097068 20686565) Type 2 diabetes ( 30054458) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		125 interacting genes: AGGF1 ARK2N AXIN2 BACH2 BEND3 BHLHA9 BHLHE40 BLM BRD8 BRMS1 BRMS1L C7orf57 C8orf34 CARD9 CATSPERT CAVIN2 CBY2 CCDC13 CCDC136 CCDC85B CCHCR1 CCNH CDCA7L CEP44 CEP70 CNTROB COIL CREB3L3 CRYAA CYSRT1 CYTIP DAXX DRAP1 DSCR9 DVL2 EGR2 ERF EVI5 FAM9A FNDC8 FSD2 FXR1 FXR2 GAS7 GCC1 GEM GIGYF1 GOLGA2 GPBP1 HMBOX1 HOOK2 IKZF1 IKZF3 IKZF4 JAKMIP1 KANK2 KAT7 KDM1A KIAA1958 KRT35 KRTAP10-7 KRTAP2-3 KRTAP2-4 KXD1 LIG4 LSM6 LZTS1 MAGEA11 MAGEA6 MAPK9 MED4 MEOX1 MFAP1 MIER2 MIER3 NAA10 NAB2 NKAPD1 NOP2 OSBPL3 PBK PBX2 PCM1 PHC2 PIBF1 PINX1 PKNOX2 PPP1R13B PRMT5 PSTPIP1 PTEN RABEP1 RALYL RARA RETREG3 RIPPLY3 SH2B2 SHANK3 SNAPC5 SP4 SRRM4 SSMEM1 SUV39H1 TADA2B TBC1D1 TERT TFAP4 TLE5 TNIP1 TNNI1 TP63 TRIM37 TRIM41 TSPYL2 UPF3B USHBP1 WASHC3 WBP11 XIAP ZBTB22 ZCCHC12 ZNF23 ZNF639 ZNF8 ZRANB1	17 interacting genes: AIDA APP C14orf119 CACYBP EIF1AD GABPA GYS1 MCRS1 MPZ PAFAH1B2 TERF1 TERT TFRC TLK1 TNPO2 TP63 UBL5
Entrez ID		10445	54984
HPRD ID		11298	05934
Ensembl ID		ENSG00000187778	ENSG00000254093
Uniprot IDs		Q96EZ8	Q96BK5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Identical Protein Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Histone Deacetylase Binding Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Protein-containing Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Nucleolus Chromatin Binding Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Protein Domain Specific Binding Chromatin Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Stem Cell Proliferation Regulation Of Nervous System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Cellular Senescence Regulation Of Centromeric Sister Chromatid Cohesion MRF Binding Telomere Maintenance Via Telomerase Sequence-specific DNA Binding	Regulation Of Protein Localization Regulation Of Protein Localization To Nucleus Nuclear Envelope Lumen Nuclear Telomere Cap Complex Telomerase Activity Regulation Of Protein Localization To Nucleolus Positive Regulation Of Protein Localization To Nucleolus Response To Manganese Ion Protein-folding Chaperone Binding Protein Homodimerization Activity Telomere Maintenance Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor Response To Leukemia Inhibitory Factor Notch Signaling Pathway RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of DNA Replication Negative Regulation Of Cellular Senescence Telomeric DNA Binding Telomere Organization Amyloid-beta Complex Growth Cone Lamellipodium Response To Copper Ion Response To Metal Ion Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Establishment Of Protein Localization To Telomere Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Telomere Maintenance Via Telomere Lengthening TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Ectoderm And Mesoderm Interaction Epidermal Cell Division Determination Of Ventral Identity Positive Regulation Of Stem Cell Proliferation Regulation Of Cellular Senescence Acetylcholine Receptor Activator Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import
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