NOD2 and ERBIN

Number of citations of the paper that reports this interaction (PubMedID 30833792)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		NOD2	ERBIN
Description		nucleotide binding oligomerization domain containing 2	erbb2 interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Extrinsic Component Of Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Nucleotide Binding Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Ubiquitin Binding Anion Binding ADP Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding Carbohydrate Derivative Binding	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Temperature Homeostasis Pattern Recognition Receptor Signaling Pathway Adaptive Immune Response Immune System Process Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Autophagy Defense Response Canonical NF-kappaB Signal Transduction Response To Nutrient Positive Regulation Of Cell Population Proliferation Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Regulation Of Appetite Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Intestinal Stem Cell Homeostasis P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Host-mediated Modulation Of Intestinal Microbiota Composition Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Protein Linear Polyubiquitination Antibacterial Innate Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Mitophagy Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses	Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Mifamurtide
Diseases		Crohn's disease Blau syndrome
GWAS		Asthma ( 32296059 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17804789 28067908 23128233 22936669 22412388 21102463 20570966 18587394 17554300) Inflammatory bowel disease ( 28067908 18758464) Leprosy ( 25642632 27976721 20018961) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		38 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP	66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		64127	55914
HPRD ID		05810	06090
Ensembl ID		ENSG00000167207	ENSG00000112851
Uniprot IDs		A0A286YF65 Q9HC29	A0A8V8TML4 A0A8V8TPC7 Q96RT1
PDB IDs			1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Response To Muramyl Dipeptide Cellular Response To Muramyl Dipeptide Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Muscle Thin Filament Tropomyosin Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nuclear Migration Response To External Biotic Stimulus Nucleus Localization Stress Fiber Cytosol Pattern Recognition Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Mitotic Spindle Organization Cellular Response To Lipopolysaccharide Innate Immune Response-activating Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagy Autophagosome Maturation Cellular Response To Molecule Of Bacterial Origin C-terminal Protein Lipidation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Activation Of Innate Immune Response Autophagosome Membrane Intracellular Transport Canonical NF-kappaB Signal Transduction P38MAPK Cascade Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Protein Deubiquitination Regulation Of Organelle Organization Vesicle Budding From Membrane Response To Lipid Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Protein Metabolic Process Organelle Localization Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Protein Linear Polyubiquitination Xenophagy Identical Protein Binding Regulation Of Protein Metabolic Process Cellular Localization Endosome Transport Via Multivesicular Body Sorting Pathway Establishment Of Localization In Cell Cellular Response To Oxygen-containing Compound Positive Regulation Of Xenophagy Positive Regulation Of Organelle Organization	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation
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