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NOD2
Gene Name
nucleotide-binding oligomerization domain containing 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
COP9 Signalosome
Cell Surface
Vesicle
Protein Complex
Molecular Function
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Muramyl Dipeptide Binding
Peptidoglycan Binding
CARD Domain Binding
Biological Process
Activation Of MAPK Activity
Toll-like Receptor Signaling Pathway
Innate Immune Response In Mucosa
Cytokine Production Involved In Immune Response
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Dendritic Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
JNK Cascade
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Response To Lipopolysaccharide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Toll-like Receptor 2 Signaling Pathway
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
Activation Of MAPK Activity Involved In Innate Immune Response
Intracellular Signal Transduction
TRIF-dependent Toll-like Receptor Signaling Pathway
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of Growth Of Symbiont In Host
Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Interleukin-1 Beta Secretion
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Oligomerization
Positive Regulation Of Oxidoreductase Activity
Stress-activated MAPK Cascade
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Macrophage Inflammatory Protein-1 Alpha Production
Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
NOD1/2 Signaling Pathway
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
Innate Immune System
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Cytokine Signaling in Immune system
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Signaling by Interleukins
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
Interleukin-1 signaling
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Crohn's disease (
18587394
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
)
Leprosy (
20018961
)
Protein-protein Interactions
5 interactors:
ERBB2IP
MAP3K7
NLRC4
RIPK2
XIAP
Entrez ID
64127
HPRD ID
05810
Ensembl ID
ENSG00000167207
Uniprot IDs
Q9HC29
PDB IDs
Enriched GO Terms of Interacting Partners
?
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Innate Immune Response
Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Intracellular Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Immune Response
Negative Regulation Of Apoptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Negative Regulation Of Programmed Cell Death
Apoptotic Process
Negative Regulation Of Cell Death
Programmed Cell Death
Cell Death
Death
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Protein Metabolic Process
Regulation Of Immune System Process
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Cell Death
MyD88-dependent Toll-like Receptor Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
JNK Cascade
Positive Regulation Of Immune Response
Toll-like Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of JNK Cascade
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Stress-activated MAPK Cascade
Tagcloud
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aspergillus
conidia
crosstalk
dipeptide
fumigates
fumigatus
hcecs
immortalized
immunity
initiating
innate
interrelationship
keratitis
leucine
mdp
muramyl
nfkappab
nlrs
oligomerization
pamps
prr
prrs
recognize
rip2
surprise
tlr2
tlrs
toll
zymosan