SDHB and SPRY2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SDHB	SPRY2
Gene Name		succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	sprouty homolog 2 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex II Extracellular Vesicular Exosome	Cytosol Microtubule Plasma Membrane Microtubule Cytoskeleton Ruffle Membrane
	Molecular Function	Protein Binding Succinate Dehydrogenase (ubiquinone) Activity Electron Carrier Activity Metal Ion Binding Ubiquinone Binding 2 Iron, 2 Sulfur Cluster Binding 3 Iron, 4 Sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Tricarboxylic Acid Cycle Succinate Metabolic Process Aerobic Respiration Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process	Establishment Of Mitotic Spindle Orientation Epidermal Growth Factor Receptor Signaling Pathway Sensory Perception Of Sound Negative Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Ras GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Cell Fate Commitment Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Lung Growth Bud Elongation Involved In Lung Branching Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Signaling by EGFR EGFR downregulation Signaling by FGFR in disease Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Spry regulation of FGF signaling Signaling by FGFR Negative regulation of FGFR signaling
Drugs
Diseases
GWAS		Height ( 20189936)	Adiposity ( 21706003) Fasting insulin-related traits (interaction with BMI) ( 22581228) Orofacial clefts ( 20023658 22863734) Type 2 diabetes ( 20862305)
Protein-Protein Interactions		5 interactors: ABCA1 GEM PIK3R5 SPRY2 XRN1	90 interactors: ADAMTSL4 AQP1 ATRIP C19orf66 CATSPER1 CBL CBLB CBLC CHRD CREB5 CRIP2 CRMP1 CSTB CTSB DGCR6 DNM2 EIF4E2 FAIM FAM219A FBN1 FRS3 GNE GP9 GPRIN2 GRAP2 GRB2 HEXIM2 HSD3B7 ITSN1 KDM1A KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LASP1 LCE1B LCE2D LCE3C LCE3E LCE4A LONRF1 MAPKBP1 MDFI MEOX2 MID2 MKNK1 MLLT6 NCK2 NEDD4 NR1H2 NUBP1 OTX1 PACSIN3 PLSCR1 PRKAB2 PTGER3 PTPN11 RAF1 RTFDC1 RUNX1T1 SDHB SEMA5B SH3KBP1 SIAH2 SPRY1 STK16 TCAF1 TRAF2 TRIM51 TXNDC5 UBASH3A UBASH3B UBR1 USP20 VPS25 VPS36 ZBTB16 ZNF266 ZNF417 ZNF587
Entrez ID		6390	10253
HPRD ID		01707	03916
Ensembl ID		ENSG00000117118	ENSG00000136158
Uniprot IDs		P21912	O43597
PDB IDs			3BUM 3OB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Kinase B Signaling Regulation Of Protein Kinase B Signaling Interleukin-1 Beta Secretion Apolipoprotein A-I-mediated Signaling Pathway Interleukin-1 Secretion Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Nuclear MRNA Surveillance Cell Surface Receptor Signaling Pathway Regulation Of MAP Kinase Activity Negative Regulation Of Cholesterol Storage Lung Growth High-density Lipoprotein Particle Assembly RNA Surveillance Establishment Of Organelle Localization Intracellular Cholesterol Transport Intracellular Sterol Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Histone MRNA Catabolic Process Phospholipid Homeostasis Platelet Dense Granule Organization Regulation Of Phosphorus Metabolic Process RRNA Catabolic Process Phospholipid Efflux Phagocytosis, Engulfment Bud Elongation Involved In Lung Branching Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Organelle Localization Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of MAPK Cascade Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Regulation Of Intracellular Signal Transduction Protein-lipid Complex Assembly Response To Lipoprotein Particle Positive Regulation Of Protein Kinase Activity Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Lipid Storage Positive Regulation Of Kinase Activity Negative Regulation Of Ras GTPase Activity Positive Regulation Of Cholesterol Transport Histone MRNA Metabolic Process Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Cholesterol Efflux Phosphatidylinositol 3-kinase Signaling	Negative Regulation Of Signaling Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Keratinization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Process Keratinocyte Differentiation Regulation Of Cell Activation Negative Regulation Of Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway Cell Death System Development Death Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell-cell Adhesion Developmental Process Multicellular Organismal Development Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of T Cell Activation Cellular Response To Organic Substance Cell Differentiation Anatomical Structure Development Organ Development Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Ubiquitination Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase Activity Epidermal Cell Differentiation Response To Growth Factor Protein Modification By Small Protein Conjugation Epithelium Development Regulation Of Apoptotic Process Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Kinase Activity Regulation Of Immune System Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		alters anatomical bacteremia bacterium colonization colonizing competitors divergent fitness frda fumc genitourinary gluconeogenesis glycolysis mirabilis niche nutritional occupying pentose pfka pgi polymicrobial proteus pyka requirements tca tpia uncomplicated uropathogenic	beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Difference) ?		alters anatomical bacteremia bacterium colonization colonizing competitors divergent fitness frda fumc genitourinary gluconeogenesis glycolysis mirabilis niche nutritional occupying pentose pfka pgi polymicrobial proteus pyka requirements tca tpia uncomplicated uropathogenic	beyond carcinogenesis carcinogenic cdh1 chfr continue detailed endometrial explained familial generations germ grow hmlh1 hypermethylation imbalance inherited involve micrornas mir mismatch mmr oncogenes pten rassf1a rsk4 unopposed worldwide younger
Tagcloud (Intersection) ?