SCTR and PRKAR2A

Number of citations of the paper that reports this interaction (PubMedID 9506976)
0

Data Source:
HPRD (in vitro)

		SCTR	PRKAR2A
Description		secretin receptor	protein kinase cAMP-dependent type II regulatory subunit alpha
Image
GO Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Secretin human	GEM-231
Diseases
GWAS		Bipolar disorder ( 31043756) Type 2 diabetes ( 30718926 32499647)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1	40 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS IFNAR2 LRIF1 MAP2 MYCBPAP NBEA OGT PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RET RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 WASF1 WEE2-AS1
Entrez ID		6344	5576
HPRD ID		01628	01484
Ensembl ID		ENSG00000080293	ENSG00000114302
Uniprot IDs		P47872 Q8IV17	A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861
PDB IDs		6WI9 6WZG 7D3S	2IZX 2KYG 4ZP3 5H78 5XBY 8S8O
Enriched GO Terms of Interacting Partners?		Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus
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