SCTR and DNAL4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SCTR	DNAL4
Description		secretin receptor	dynein axonemal light chain 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane	Cytoplasm Cytoskeleton Microtubule Plasma Membrane Cilium Dynein Complex Cell Projection
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity	Microtubule-based Process Microtubule-based Movement
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	Retrograde neurotrophin signalling
Drugs		Secretin human
Diseases
GWAS		Bipolar disorder ( 31043756) Type 2 diabetes ( 30718926 32499647)
Interacting Genes		9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1	14 interacting genes: CHIC2 DYNLL2 FHL5 GNA14 GPBP1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 SCTR TRIM54
Entrez ID		6344	10126
HPRD ID		01628	13239
Ensembl ID		ENSG00000080293	ENSG00000100246
Uniprot IDs		P47872 Q8IV17	O96015
PDB IDs		6WI9 6WZG 7D3S
Enriched GO Terms of Interacting Partners?		Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane
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