SCTR and CYFIP1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		SCTR	CYFIP1
Name		secretin receptor	cytoplasmic FMR1 interacting protein 1
Structure
GO Annotations	Cellular Component	Cytoplasmic Microtubule Plasma Membrane Membrane Basolateral Plasma Membrane	Ruffle Extracellular Region Cytoplasm Cytosol Focal Adhesion Lamellipodium SCAR Complex Cell Leading Edge Secretory Granule Lumen Specific Granule Lumen Cell Projection Neuron Projection Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Tertiary Granule Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Peptide Receptor Activity Secretin Receptor Activity Peptide Hormone Binding	RNA 7-methylguanosine Cap Binding Actin Binding Protein Binding Translation Repressor Activity Small GTPase Binding Actin Filament Binding
	Biological Process	Diet Induced Thermogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Water Homeostasis Response To Nutrient Levels Regulation Of Appetite Regulation Of Synaptic Plasticity	Cell Morphogenesis Regulation Of Translation Nervous System Development Axon Guidance Regulation Of Cell Shape Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Negative Regulation Of Translation Lamellipodium Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Neuron Projection Development Ruffle Organization Axon Extension Cognition Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Dendrite Extension Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Secretin human	None
GWAS		Bipolar disorder ( 31043756 ) Type 2 diabetes ( 30718926 32499647 )	Bipolar disorder ( 34099189 ) Heel bone mineral density ( 30598549 ) Platelet distribution width ( 32888494 ) Triglyceride levels x loop diuretics use interaction ( 31806883 ) World class endurance athleticism ( 32612638 )
Novel Interactors		None recorded	1 novel interactors: NUP98
Interacting Genes		9 interacting genes: ADCYAP1 CALM1 CPAMD8 CYFIP1 DNAL4 PRKAR2A PRKCA SCT SNTA1	19 interacting genes: ACTA1 APBB1 EFHC2 EFTUD2 EIF4E FMR1 FXR2 GAS7 GNB1 MEOX1 MYO16 NYAP1 NYAP2 PPP1CC PRPF40A RAC1 RFX6 SCTR TCERG1
Entrez ID		6344	23191
HPRD ID		01628	05890
Ensembl ID		ENSG00000080293	ENSG00000273749
Uniprot IDs		P47872 Q8IV17	Q7L576
PDB IDs		6WI9 6WZG 7D3S	3P8C 4N78 7USC 7USD 7USE
GO Terms Enriched among Interactors		Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Regulation Of System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Hormone Secretion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion Pituitary Adenylate Cyclase Activating Polypeptide Activity Positive Regulation Of Secretion By Cell Protein-containing Complex Positive Regulation Of Somatostatin Secretion Negative Regulation Of Gastrin-induced Gastric Acid Secretion Digestive Hormone Activity Regulation Of Transport Positive Regulation Of Signal Transduction Regulation Of Biological Quality Positive Regulation Of Cell Communication Signaling Receptor Binding Type 2 Vasoactive Intestinal Polypeptide Receptor Binding Type 1 Vasoactive Intestinal Polypeptide Receptor Binding Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Positive Regulation Of Pancreatic Juice Secretion Regulation Of Heart Rate Regulation Of Signal Transduction Hormone Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Protein Kinase C Signaling Negative Regulation Of Gastric Acid Secretion Syntrophin Complex Regulation Of Translation At Postsynapse Regulation Of Hormone Levels Extracellular Region Transmembrane Transporter Binding Regulation Of Secretion By Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane	Cell Projection Morphogenesis Neuron Projection Morphogenesis Cytoplasmic Ribonucleoprotein Granule Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Postsynapse Nuclear Speck MRNA Transport RNA Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Nucleobase-containing Compound Transport RNA Export From Nucleus Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cytoplasmic Stress Granule RNA Binding Developmental Process Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Intracellular Signaling Cassette Nuclear Export Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Secretion Protein-containing Complex Binding Neuron Differentiation RNA Splicing Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Dendritic Spine Development Presynaptic Modulation Of Chemical Synaptic Transmission Cell Projection Organization Eukaryotic Initiation Factor 4G Binding Positive Regulation Of Intracellular Transport Of Viral Material Telomere Tethering At Nuclear Periphery Secretin Receptor Activity Pancreatic Epsilon Cell Differentiation Lamellipodium MRNA Processing Molecular Condensate Scaffold Activity Regulation Of Dendritic Spine Development Dendritic Filopodium Positive Regulation Of Neurogenesis Histone H3 Reader Activity Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Pancreatic D Cell Differentiation